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The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells

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Abstract

The human major histocompatibility complex (HLA) has been demonstrated to play two roles in the generation and expression of cytotoxic T-lymphocyte responses to virusinfected cells: (1) cytotoxic T cells can only recognize viral antigens in conjunction with antigens encoded by HLA-A and -B genes; and (2) HLA-linked genes may control the capacity to generate T-cell responses to a given virus or to virus in conjunction with particular self HLA-A and -B antigens. Analysis of T-cell responses generatedin vivo to Epstein-Barr virus suggests that human T cells may recognize virus in conjunction with antigens other than the class I HLA polymorphic specificities.

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References

  1. Zinkernagel RM, Doherty PC: MHC-restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol 27:52–180, 1979

    Google Scholar 

  2. Bodmer WF: The HLA system. Br Med Bull 34:213–246, 1978

    Google Scholar 

  3. Goodfellow PN, Jones EA, Heyningen VV, Solomon S, Bobrow M, Miggiano V, Bodmer WF. The β2M gene is on chromosome 15 and not in the HLA region. Nature 254:267–269, 1975

    Google Scholar 

  4. Strominger JL, Engelhard VH, Fuks A, Guild BC, Hyafil F, Kaufman JF, Korman AJ, Kostyk TG, Krangel MS, Lancet D, Lopez de Castro JA, Mann DL, Orr HT, Parham PR, Parker KC, Ploegh HL, Pober JS, Robb RJ, Shackelford DA. The biochemical analysis of products of the major histocompatibility complex.In The Role of the MHC in Immunobiology, ME Dorf (ed). New York, Garland STPM Press, 1981

    Google Scholar 

  5. Bull WHO 58:945, 1980

  6. Shaw S, Johnson AH, Shearer GM: Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogeneic proliferative and cytotoxic responses. J Exp Med 152:565–580, 1980

    Google Scholar 

  7. Shaw S, Kavathas P, Pollack MS, Charmot D, Mawas C: Family studies define a new histocompatibility Iocus, SB, between HLA-DR and GLO. Nature (in press), 1981

  8. Orr HT, Lopez de Castro JA, Parham P, Ploegh HL, Strominger JL: Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: Locations of putative alloantigenic sites. Proc Natl Acad Sci (USA) 76:4395–4400, 1979

    Google Scholar 

  9. Biddison WE, Shearer GM, Shaw S: Influenza virus-specific cytotoxic T cells are restricted by multiple HLA-A3-related self antigens: Evidence for recognition of distinct self structures in conjunction with different foreign antigens. J Immunol (in press), 1981

  10. Brodsky FM, Parham P, Barnstable CJ, Crumpton MJ, Bodmer WF: Monoclonal antibodies for analysis of the HLA system. Immunol Rev 47:3–61, 1979

    Google Scholar 

  11. Hansen TH, Ozato K, Melino MR, Coligan JE, Kindt TJ, Jandinski JJ, Sachs DH: Immunochemical evidence in two haplotypes for at least threeD region-encoded molecules, D, L, and R. J Immunol 126:1713–1716, 1981

    Google Scholar 

  12. Berke G: Interaction of cytotoxic T lymphocytes and target cells. Prog Allergy 27:69–133, 1980

    Google Scholar 

  13. Golstein P, Smith ET: Mechanism of T cell-mediated cytolysis: The lethal hit stage. Contemp Top Immunobiol 7:273–301, 1977

    Google Scholar 

  14. Henney CS: T-cell-mediated cytolysis: An overview of some current issues. Contemp Top Immunobiol 7:245–272, 1977

    Google Scholar 

  15. Martz E: Mechanisms of specific tumor cell lysis of alloimmune T-lymphocytes: Resolution and characterization of discrete steps in the cellular interaction. Contemp Top Immunobiol 7:301–361, 1977

    Google Scholar 

  16. Zagury D, Bernard J, Thierness N, Feldman M, Berke G: Isolation and characterization of individual functionally reactive cytotoxic T lymphocytes: Conjugation, killing and recycling at the single cell level. Eur J Immunol 5:818–822, 1975

    Google Scholar 

  17. Yap KL, Ada GL, McKenzie IFC: Transfer of specific cytotoxic T lymphocytes protects mice inoculated with influenza virus. Nature 273:238–239, 1978

    Google Scholar 

  18. Yap KL, Ada GL: The recovery of mice from influenza A virus infection: Adoptive transfer of immunity with influenza virus-specific cytotoxic T lymphocytes recognizing a common virion antigen. Scand J Immunol 8:413–420, 1978

    Google Scholar 

  19. Lin Y-L, Askonas BA: Biological properties of an influenza A virus-specific killer T cell clone. Inhibition of virus replication in vivo and induction of delayed type hypersensitivity reactions. J Exp Med 154:225–234, 1981

    Google Scholar 

  20. McMichael AJ, Ting A, Zweerink HJ, Askonas BA: HLA restriction of cell-mediated lysis of influenza virus-infected human cells. Nature 270:524–526, 1977

    Google Scholar 

  21. McMichael AJ, Askonas BA: Influenza virus-specific cytotoxic T cells in man; induction and properties of the cytotoxic cell. Eur J Immunol 8:705–711, 1978

    Google Scholar 

  22. McMichael A: HLA restriction of human cytotoxic T lymphocytes specific for influenza virus. Poor recognition of virus associated with HLA-A2. J Exp Med 148:1458–1467, 1978

    Google Scholar 

  23. McMichael AJ, Parham P, Brodsky FM, Pilch JR: Influenza virus-specific cytotoxic T lymphocytes recognize HLA molecules. Blocking by monoclonal anti-HLA antibodies. J Exp Med 152:195s-203s, 1980

    Google Scholar 

  24. Biddison WE, Shaw S, Nelson DL: Virus specificity of human influenza virus-immune cytotoxic T cells. J Immunol 122:660–664, 1979

    Google Scholar 

  25. Shaw S, Biddison WE: HLA-linked genetic control of the specificity of human cytotoxic T cell responses to influenza virus. J Exp Med 149:565–575, 1979

    Google Scholar 

  26. Biddison WE, Shaw S: Differences in HLA antigen recognition by human influenza virus-immune cytotoxic T cells. J Immunol 122: 1705–1709, 1979

    Google Scholar 

  27. Biddison WE, Ward FE, Shearer GM, Shaw S: The self determinants recognized by human virus-immune T cells can be distinguished from the serologically defined HLA antigens. J Immunol 124:548–552, 1980

    Google Scholar 

  28. Shaw S, Shearer GM, Biddison WE: Human cytotoxic T cell responses to type A and type B influenza viruses can be restricted by different HLA antigens. Implications for HLA polymorphism and genetic regulation. J Exp Med 151:235–245, 1980

    Google Scholar 

  29. Biddison WE, Payne SM, Shearer GM, Shaw S: Human cytotoxic T cell responses to trinitrophenyl hapten and influenza virus. Diversity of restriction antigens and specificity of HLA-linked genetic regulation. J Exp Med 152:204s-217s, 1980

    Google Scholar 

  30. Biddison WE, Krangel MS, Strominger JL, Ward FE, Shearer GM, Shaw S: Virus-immune cytotoxic T cells recognize structural differences between serologically indistinguishable HLA-A2 molecules. Hum Immunol 3:225–232, 1980

    Google Scholar 

  31. McMichael AJ: HLA restriction of human cytotoxic T cells. Springer Semin Immunopathol 3:3–22, 1980

    Google Scholar 

  32. Daisy JA, Tolpin MD, Quinnan GV, Rook AH, Murphy BR, Mittal K, Clements ML, Mullinix MG, Kileg SC, Ennis FA: Cytotoxic cellular immune responses during influenza A infection in human volunteers.In The Replication of Negative Strand Viruses, DHL Bishop, RW Compans (eds). New York, Elsevier North-Holland, 1981, pp 443–448

    Google Scholar 

  33. Ennis FA, Rook AH, Yi-Hua Q, Riley D, Pratt R, Potter CW, Schild G: HLA restricted virus specific cytotoxic T lymphocyte responses to live and inactivated influenza vaccines. Lancet (in press), 1981

  34. Lipinski M, Fridman WH, Tursz T, Vincent C, Pious D, Fellous M: Absence of allogeneic restriction in human T-cell-mediated cytotoxicity to Epstein-Barr virus-infected target cells. Demonstration of an HLA-linked control at the effector level. J Exp Med 150:1310–1322, 1979

    Google Scholar 

  35. Tursz T, Fridman WH, Senik A, Tsapis A, Fellous M: Human virus-infected target cells lacking HLA antigens resist specific T-lymphocyte cytolysis. Nature 269:806–809, 1977

    Google Scholar 

  36. Seeley J, Svedmyr E, Weiland O, Klein G, Moller E, Eriksson E, Andersson K, van der Waal L: Epstein-Barr virus selective T cells in infectious mononucleosis are not restricted to HLA-A and -B antigens. J Immunol 127:298–300, 1981

    Google Scholar 

  37. Misko IS, Moss DJ, Pope JH: HLA antigen-related restriction of T lymphocyte cytotoxicity to Epstein-Barr virus. Proc Natl Acad Sci (USA) 77:4247–4250, 1980

    Google Scholar 

  38. Tsoukas CD, Fox RI, Slovin SF, Carson DA, Pellegrino M, Fong S, Pasquali J-L, Ferrone S, Kung P, Vaughan JH: T lymphocyte-mediated cytotoxicity against autologous EBV-genome-bearing B cells. J Immunol 126:1742–1746, 1981

    Google Scholar 

  39. Kreth HW, ter Meulen V, Eckert G: Demonstration of HLA restricted killer cells in patients with acute measles. Med Microbiol Immunol 165:203–214, 1979

    Google Scholar 

  40. Wright LL, Levy NL: Generation on infected fibroblasts of human T and non-T lymphocytes with specific cytotoxicity, influenced by histocompatibility, against measles virus-in-fected cells. J Immunol 122:2379–2387, 1979

    Google Scholar 

  41. Sethi KK, Stroehmann I, Brandis H: Human T-cell cultures from virus-sensitized donors can mediate virus-specific and HLA-restricted cell lysis. Nature 286:718–720, 1980

    Google Scholar 

  42. Quinnan GV, Kirmani N, Esber E, Saral R, Manischewitz JF, Rogers JL, Rook AH, Santos GW, Burns WH: HLA-restricted cytotoxic T lymphocyte and nonthymic cytotoxic lymphocyte responses to cytomegalovirus infection of bone marrow transplant recipients. J Immunol 126:2036–2041, 1981

    Google Scholar 

  43. Goulmy E, Termijtelen A, Bradley BA, van Rood JJ: Y-antigen killing by T cells of women is restricted by HLA. Nature 266:544–545, 1977

    Google Scholar 

  44. Goulmy E, Bradley BA, Lansbergen Q, van Rood JJ: The importance of H-Y incompatibility in human organ transplantation. Transplantation 25:315–319, 1978

    Google Scholar 

  45. Goulmy E, Hamilton JD, Bradley BA: Anti-self HLA may be clonally expressed. J Exp Med 149:545–550, 1979

    Google Scholar 

  46. Dickmeiss E, Soeberg B, Svejgaard A: Human cell-mediated cytotoxicity against modified target cells is restricted by HLA, Nature 270:526–528, 1977

    Google Scholar 

  47. Shaw S, Nelson DL, Shearer GM: Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. I. T cells recognition of TNP in association with widely shared antigens. J Immunol 121:281–289, 1978

    Google Scholar 

  48. Shaw S, Shearer GM: Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. II. Diversity of self determinants recognized in association with TNP. J Immunol 121:290–299, 1978

    Google Scholar 

  49. Doherty PC, Zinkernagel RM: Immune surveillance and the role of major histocompatibility antigens. Lancet I:1406–1409, 1975

    Google Scholar 

  50. Biddison WE, Sharrow SO, Shearer GM: T cell subpopulations required for the human cytotoxic T lymphocyte response to influenza virus: Evidence for T cell help. J Immunol 127:487–491, 1981

    Google Scholar 

  51. Lamb JR, Eckels DD, Lake P, Woody JN, Johnson AH, Hartzman RJ: Antigen-specific human T-lymphocyte clones: Induction, antigen specificity, and genetic restriction of influenza-immune clones. J Immunol (in press), 1981

  52. Zhang Y-H, Nelson DL, Biddison WE: Ia-positive accessory cells are required for the induction of human influenza virus-immune cytotoxic T lymphocytes. Proc 14th Int Leu Cult Conf (in press), 1981

  53. Doherty PC, Zinkernagel RM: Capacity of sensitized thymus derived lymphocytes to induce fatal lymphocytic choriomeningitis is restricted by the H-2 gene complex. J Immunol 114:30–33, 1975

    Google Scholar 

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  1. Neuroimmunology Branch, National Institute of Neurological, Communicative Disorders, and Stroke, National Institutes of Health, Building 36. Room 5D-14, 20205, Bethesda, Maryland

    William E. Biddison

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Biddison, W.E. The role of the human major histocompatibility complex in cytotoxic T-cell responses to virus-infected cells. J Clin Immunol 2, 1–9 (1982). https://doi.org/10.1007/BF00915971

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