International Ophthalmology

, Volume 18, Issue 3, pp 167–170 | Cite as

Occlusion of the retinal vasculature after trabeculectomy with mitomycin C

  • Rudy M. M. A. Nuyts
  • HarriËt A. M. Van Diemen
  • Erik L. Greve


A 45-year-old male underwent a trabeculectomy with mitomycin C for a secondary glaucoma after complicated cataract surgery. Because of early bleb failure a needling procedure with subconjunctival injection of mitomycin C was performed. Five days postoperatively the patient developed an occlusion of both the arterial and venous retinal vasculature. A relation between the diffusion of mitomycin C into the vitreous cavity and the development of retinal toxicity is suggested.

Key words

trabeculectomy mitomycin C vascular occlusion retina toxicity 


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  1. 1.
    Nuyts RMMA, Pels E, Greve EL. The effects of 5-fluorouracil and mitomycin C on the corneal endothelium. Curr Eye Res 11: 565, 1992.Google Scholar
  2. 2.
    Derick RJ, Pasquale L, Quigley HA, Jampel HD. Potential toxicity of mitomycin C. Arch Ophthalmol 109: 1635, 1992.Google Scholar
  3. 3.
    McDermott ML, Wang J, Shin DH. Mitomycin and the human corneal endothelium. Arch Ophthalmol 112: 533, 1994.Google Scholar
  4. 4.
    Rubinfeld RS, Pfister RR, Stein RM, Foster CS, Martin NF, Stoleru S, et al. Serious complications of topical mitomycin C after pterygium surgery. Ophthalmology 99: 1647, 1993.Google Scholar
  5. 5.
    Yamanouchi U, Mishima K. Eye lesions due to mitomycin C installation after pterygium operation. Folia Ophthalmol Jpn 29: 1221, 1978.Google Scholar
  6. 6.
    Yamanouchi U, Takaku I, Tsuda N, Kajiwara Y, Mine M, Ueno Y, et al. Scleromalacia presumably due to mitomycin C installation after pterygiumexcision. Jpn J Clin Ophthalmol 33: 139, 1979.Google Scholar
  7. 7.
    Yamanouchi U. A case of scleral calcification due to mitomycin C installation after pterygium excision. Folia Ophthalmol Jpn 18: 854, 1967.Google Scholar
  8. 8.
    Fukumachi Y, Hikita N. Ocular complications following pterygium operation and installation of mitomycin C. Folia Ophthalmol Jpn 32: 197, 1981Google Scholar
  9. 9.
    Singh G. Wilson MR, Foster CS. Mitomycin eye drops as treatment for pterygium. Ophthalmology 95: 813, 1988Google Scholar
  10. 10.
    Hayasaka S, Noda S, Yamamoto Y, Setogawa T. Postoperative installation of low-dose mitomycin C in the treatment of primary pterygia. Am J Ophthalmol 106: 715, 1988.Google Scholar
  11. 11.
    Hayasaka S, Noda S, Yamamoto Y, Setogawa T. Postoperative installation of mitomycin C in the treatment of recurrent pterygia. Ophthalmic Surg 20: 580, 1989.Google Scholar
  12. 12.
    Nuyts RMMA, Felten PC, Pels E, Langerhorst CT, Geijssen HC, Grossniklaus HE, Greve EL. Histopathologic effects of mitomycin C in human glaucomatous eyes with persistent hypotony after trabeculectomy. Am J Ophthalmol 1994 (in press).Google Scholar
  13. 13.
    Kawase K, Matsushita H, Yamamoto T, Kitazawa Y. Mitomycin concentration in rabbit and human ocular tissues after topical administration. Ophthalmology 99: 203, 1992Google Scholar
  14. 14.
    Sarraf D, Eezzuduemhoi RD, Cheng Q, Wilson MR, Lee DA. Aqueous and vitreous concentration of mitomycin C by topical administration after glaucoma filtration surgery in rabbits. Ophthalmology 100: 1574, 1993.Google Scholar
  15. 15.
    Seah SKL, Prata Jr JA, Minckler DS, Koda RT, Baerveldt G, Lee PP, Heuer DK. Mitomycin C concentration in human aqueous humour following trabeculectomy. Eye 7: 652, 1994.Google Scholar
  16. 16.
    Peyman GA, Greenberg D, Fishman GA, Fiscella R, Thomas A. Evaluation of toxicity of intravitreal antineoplastic drugs. Ophthalmic Surg 15: 411, 1984.Google Scholar
  17. 17.
    Verweij J, Stoter G. Severe side effects of the cytotoxic drug mitomycin C. Neth J Med 30: 43, 1987.Google Scholar
  18. 18.
    Bikkers THA, Verweij J, Van Geel AN, Stoter G. Severe tissue necrosis after extravasation of mitomycin C. Ned Tijdschr Geneesk 131: 588, 1987.Google Scholar

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Rudy M. M. A. Nuyts
    • 1
  • HarriËt A. M. Van Diemen
    • 1
  • Erik L. Greve
    • 1
  1. 1.The Glaucoma Center, Department of Ophthalmology, Academic Medical CenterUniversity of AmsterdamThe Netherlands

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