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Substance-P-like levels in inflammatory exudates

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Abstract

Levels of SP-like immunoreactivity were assessed by enzyme immunoassay in exudates induced in the rat by intrapleural injection of either calcium pyrophosphate (CaPP) or carrageenan. SP-like levels increased during the first hour, up to approximately 2 ng/ml, and remained significantly higher than control values from 1 to 6 h after the induction of pleurisy by CaPP. With carrageenan as the irritant, SP-like levels rose during the first 4 h, up to 3 ng/ml, and remained significantly higher than control values from 4 to 24 h. In terms of the total volume of exudate induced by carrageenan, total amounts increased up to 8 ng/rat at 16 h after the beginning of the reaction. Our data demonstrate a detectable release of SP-like material in these pleural exudates and suggest its involvement in the inflammatory response, either directly, or through other mediators, or simply by acting on nociceptive fibers and inducing vascular changes.

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Authors and Affiliations

  1. Département de Pharmacologie, CNRS UA 595, CHU Cochin-Port Royal, 27, rue du Fbg Saint-Jacques, 75674, Paris Cedex 14, France

    M. Tissot & J. P. Giroud

  2. Section de Pharmacologie et d'Immunologie, Laboratoire d'Etudes Radioimmunologiques Département de Biologie, Commissariat à l'Energie Atomique Centre d'Etudes Nucléaires/Saclay, 91191, Gif sur Yvette Cedex, France

    P. Pradelles

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Tissot, M., Pradelles, P. & Giroud, J.P. Substance-P-like levels in inflammatory exudates. Inflammation 12, 25–35 (1988). https://doi.org/10.1007/BF00915889

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