, Volume 10, Issue 4, pp 455–461 | Cite as

Thrombin-induced calcium-independent degranulation of human neutrophils

  • Danny Baranes
  • Jacob Matzner
  • Ehud Razin
Original Articles


Thrombin, a highly specific coagulation factor, can rapidly trigger lysozyme release from human neutrophils without concomitant activation of the 5-lipoxygenase pathway. This activation was not dependent on the presence of extracellular calcium. Since thrombin also induces the release of hemostatic and inflammatory metabolites from platelets and mast cells, it is proposed that it plays a significant role in amplification of the inflammatory response.


Public Health Calcium Internal Medicine Inflammatory Response Significant Role 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Danny Baranes
    • 1
  • Jacob Matzner
    • 2
  • Ehud Razin
    • 1
  1. 1.Institute of BiochemistryThe Hebrew University-Hadassah Medical SchoolIsrael
  2. 2.The Hematology DepartmentHadassah University HospitalJerusalemIsrael

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