, Volume 8, Supplement 1, pp S49–S55 | Cite as

Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

  • James S. Goodwin
  • Jan L. Ceuppens
  • Martin A. Rodriguez
The Inlammatory Process Implications for Rheumatological Disease


The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0μg/ml), carprofen (10μg/ml) and piroxicam (10μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.


Public Health Rheumatoid Arthritis Arthritis Internal Medicine Inhibitory Action 
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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • James S. Goodwin
    • 1
  • Jan L. Ceuppens
    • 2
  • Martin A. Rodriguez
    • 3
  1. 1.Department of MedicineUniversity of New Mexico School of MedicineAlbuquerque
  2. 2.Division of Clinical Immunology Department of Medicine, St. Raphael HospitalUniversity of LeuvenLeuvenBelgium
  3. 3.Centro Nacional de Enfermedades ReumaticasMSASCarmelitas, CaracasVenezuela

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