Inflammation

, Volume 8, Supplement 1, pp S49–S55 | Cite as

Inhibition of rheumatoid factor production by non-steroidal anti-inflammatory drugs

  • James S. Goodwin
  • Jan L. Ceuppens
  • Martin A. Rodriguez
The Inlammatory Process Implications for Rheumatological Disease

Abstract

The effects of NSAIDs on IgM rheumatoid factor production in vitro and on serum rheumatoid factor concentration in vivo were investigated using indomethacin (5.0μg/ml), carprofen (10μg/ml) and piroxicam (10μg/ml). IgM rheumatoid factor was isolated from lymphocytes of patients suffering from rheumatoid arthritis. NSAIDs inhibited IgM rheumatoid factor production in vitro. Furthermore, serum IgM rheumatoid factor was reduced when NSAIDs were administered in vivo. It is thought that NSAIDs effectively remove suppressor T-cells from the tonic inhibitory action of PGE2. This previously unrecognized action of NSAIDs may be a factor in their efficacy in rheumatoid arthritis.

Keywords

Public Health Rheumatoid Arthritis Arthritis Internal Medicine Inhibitory Action 

References

  1. 1.
    Vane, J. R. 1971. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.Nature New Biol. 231:232–235.Google Scholar
  2. 2.
    Ceuppens, J. L., M. A. Rodbiguez, andJ. S. Goodwin. 1982. Nonsteroidal anti-inflammatory agents inhibit the synthesis of IgM rheumatoid factor in vitro.Lancet,1:528–530.Google Scholar
  3. 3.
    Ceuppens, J. L., andJ. S. Goodwin. 1982. Endogenous prostaglandin E2 enhances polyclonal immunoglobulin production by tonicauy inhibiting T suppressor cell activity.Cell Immunol. 70:41–54.Google Scholar
  4. 4.
    Robinson, D. R. andL. Levine. 1975. Prostaglandin concentrations in synovial fluid in rheumatic diseases: action of indomethacin and aspirin.In Prostaglandin synthetase inhibitors. H. J. Robinson, and J. R. Vane, editors.Roy Soc. Med. Raven Press, New York. 223–228.Google Scholar
  5. 5.
    Goodwin, J. S., J. L.Ceuppens, and M. A.Rodriguez. 1983. Administration of nonsteroidal anti-inflammatory agents in patients with rheumatoid arthritis.JAMA, (in press).Google Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • James S. Goodwin
    • 1
  • Jan L. Ceuppens
    • 2
  • Martin A. Rodriguez
    • 3
  1. 1.Department of MedicineUniversity of New Mexico School of MedicineAlbuquerque
  2. 2.Division of Clinical Immunology Department of Medicine, St. Raphael HospitalUniversity of LeuvenLeuvenBelgium
  3. 3.Centro Nacional de Enfermedades ReumaticasMSASCarmelitas, CaracasVenezuela

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