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Journal of Clinical Immunology

, Volume 1, Issue 2, pp 90–93 | Cite as

Impaired antibody responses to a pneumococcal polysaccharide vaccine in patients with non-Hodgkin's lymphoma in remission

  • Oscar F. Ballester
  • Muhammad Shurafa
  • Howard Toben
  • Kapisthalam S. Kumar
  • C. Lynne Burek
Original Articles

Abstract

Eight patients with non-Hodgkin's lymphoma who have been in complete clinical remission for a mean of 23.3 months were evaluated for their antibody responses to a pneumococcal vaccine. The results were correlated with lymphocyte subpopulations, serum immunoglobulin levels, andin vitro mitogenic responses to phytohemagglutinin, concanavalin and pokeweed mitogen. Two patients with normal antibody responses had immunoglobulin levels and mitogenesis within the range of controls. Impaired antibody responses in the remaining six patients were correlated either with marked depressed mitogenesis to phytohemagglutinin or with low levels of IgA. Impaired humoral immune responses seem to persist in these patients even after several months of sustained clinical remission.

Key words

Lymphoma immunity antibodies vaccine pneumococcal 

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Copyright information

© Plenum Publishing Corporation 1981

Authors and Affiliations

  • Oscar F. Ballester
    • 1
  • Muhammad Shurafa
    • 1
  • Howard Toben
    • 1
  • Kapisthalam S. Kumar
    • 1
  • C. Lynne Burek
    • 1
  1. 1.Department of Medicine, Division of Hematology, and Department of ImmunologyWayne State University, and Harper-Grace HospitalDetroit

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