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Oncological consequences of impaired immune surveillance against ubiquitous viruses

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Abstract

The immune system is constantly challenged by ubiquitous viruses. Multiple immune defenses have evolved to meet these challenges, and thus immunocompetent individuals successfully respond to infection without sequela. X-linked lymphoproliferative syndrome patients, renal allograft recipients, and acquired immunodeficiency syndrome patients share impaired immune surveillance as a common feature. Such individuals are variously susceptible to numerous untoward complications following infection with Epstein-Barr virus, cytomegalovirus, herpes simplex virus, human papillomavirus, and hepatitis B virus. We hypothesize that failure of the immune system to control these viruses is instrumental in the occurrence of some B-cell lymphomas, Kaposi's sarcoma, and squamous-cell and hepatocellular carcinomas, Herein we review some mechanisms responsible for the breakdown of immune surveillance and the permissive role immunodeficiency plays in viral oncogenesis.

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References

  1. Ehrlich P: Uber den jetzigen Stand der Karzinomforschung.In The Collected Papers of Paul Ehrlich, F Himmelweit (ed). London, Permagon Press, 1957, Vol II, pp 550–562

    Google Scholar 

  2. Thomas L: Discussion.In Cellular and Humoral Aspects of the Hypersensitive States, HS Lawrence (ed). New York, Hoeber-Harper, 1959, pp 529–532

    Google Scholar 

  3. Burnet FM: Immunological Surveillance. New York, Oxford University Press, 1970

    Google Scholar 

  4. Gatti RA, Good RA: Occurrence of malignancies in immunodeficiency diseases. A literature review. Cancer 28:89–91, 1971

    Google Scholar 

  5. Starzl TE, Penn I: Iatrogenic alterations of immunologic surveillance in man and their influence on malignancy. Transplant Rev 7:112–145, 1971

    Google Scholar 

  6. Gottlieb MS, Schroff R, Schanker HM,et al. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: Evidence of a new acquired cellular immunodeficiency. N Engl J Med 305:1425–1431, 1981

    Google Scholar 

  7. Stahl RE, Friedman-Kien A, Dubin R, Marmor M, Zolla-Pazner S: Immunologic abnormalities in homosexual men: Relationship of Kaposi's sarcoma. Am J Med 73:171–178, 1982

    Google Scholar 

  8. Sonnabend J, Witkin S, Purtilo DT: Hypothesis of Etiologic factors in pathogenesis of acquired immunodeficiency syndrome (AIDS), opportunistic infections and malignancies in male homosexuals. JAMA 249:2370–2374, 1983A

    Google Scholar 

  9. Higginson J: Overview. J Environ Pathol Toxicol 3:113–125, 1980

    Google Scholar 

  10. Gannicliffe A, Sutton RNP: Human papoviruses. J Infect 5:3–17, 1982

    Google Scholar 

  11. Spector B, Perry G, Kersey J: Genetically determined immunodeficiency diseases (GDID) and malignancy: Report from the Immunodeficiency-Cancer Registry. Clin Immunol Immunopathol 11:12–29, 1978

    Google Scholar 

  12. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Purtilo DT, Simmons RL: Lymphoproliferative diseases in renal allograft recipients.In Immunodeficiency and Cancer: Epstein-Barr Virus and Malignancies, DT Purtilo (ed). New York, Plenum Press (in press), 1983

    Google Scholar 

  13. Dulbecco R: Cell transformation by viruses. Science 166:962–968, 1969

    Google Scholar 

  14. Klein G: The role of gene dosage and genetic transpositions in carcinogenesis. Nature 294:313–318, 1981

    Google Scholar 

  15. Purtilo DT: Immunodeficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies. New York, Plenum Press (in press), 1983

    Google Scholar 

  16. Herberman RB: NK Cells and Other Natural Effector Cells. New York, Academic Press, 1982

    Google Scholar 

  17. Roder JC: A new immunodeficiency disorder in human involving NK cells. Nature 284:533–535, 1980

    Google Scholar 

  18. Merino F: Immunodeficiency to Epstein-Barr virus in Chediak-Higashi syndrome.In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York, Plenum Press, 1983

    Google Scholar 

  19. Royston I, Sullivan JL, Periman PO, Perlin E: Cell-mediated immunity to Epstein-Barr-virus-transformed lymphoblastoid cells in acute infectious mononucleosis. N Engl J Med 293:1159–1163, 1975

    Google Scholar 

  20. Henle W, Henle G, Horowitz CA: Epstein-Barr virus specific diagnostic tests in infectious mononucleosis. Human Pathol 5:551–565, 1974

    Google Scholar 

  21. Pearson GR, Orr TW: Antibody-dependent lymphocyte cytotoxicity against cells expressing Epstein-Barr virus antigen. J Natl Cancer Inst 56:485–488, 1976

    Google Scholar 

  22. Harada S, Bechtold T, Purtilo DT: Cell-Mediated immunity to Epstein-Barr virus (EBV) and natural killer (NK)-cell activity of X-linked lymphoproliferative syndrome. Int J Cancer 216:739–744, 1982

    Google Scholar 

  23. Rickinson AB, Wallace LE, Epstein MA: HLA-restricted T cell recognition of Epstein-Barr virus-infected B cells. Nature 283:865–867, 1980

    Google Scholar 

  24. Rickinson AB, Moss DJ, Wallace LE, Rowe J, Misko IS, Epstein MA, Pope JH: Long-term cell-mediated T-cell-mediated immunity to Epstein-Barr virus. Cancer Res 41:4216–4221, 1981

    Google Scholar 

  25. Purtilo DT, Yang JPS, Cassel CK, Harper P, Stephenson SR, Landing BH, Vawter GF: X-linked recessive progressive combined variable immunodeficiency (Duncan's disease). Lancet 1:935–950, 1975

    Google Scholar 

  26. Purtilo DT: Hypothesis: Pathogenesis and phenotypes of an X-linked recessive lymphoproliferative syndrome. Lancet 2:882–885, 1976

    Google Scholar 

  27. Purtilo DT, Sakamoto K, Barnabei V, Seeley J, Bechtold T, Rogers G, Yetz J, Harada S: Epstein-Barr virus-induced diseases in males with the X-linked lymphoproliferative syndrome (XLP). Am J Med 73:49–56, 1982

    Google Scholar 

  28. Lindsten T, Seeley JK, Sakamoto K, Yetz J, Harada S, Bechtold T, Rogers G, Purtilo DT: Immune deficiency in the X-linked lymphoproliferative syndrome. II. Immunoregulatory T cell defects. J Immunol 129:2536–2540, 1982

    Google Scholar 

  29. Purtilo DT: Immunopathology of infectious mononucleosis and other complications of Epstein-Barr virus infections.In Pathology Annual, 1980, SC Sommers, PP Rosen (eds). New York, Appleton-Century-Crofts 1980, pp. 253–299

    Google Scholar 

  30. Harada S, Tatsumi E, Lipscomb H, Purtilo DT: Responses to Epstein-Barr virus in immune deficient patients.In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York, Plenum Press (in press), 1983

    Google Scholar 

  31. Neudorf SML, Filipovich AH, Kersey JH: Immunoreconstitution by bone marrow transplantation decreases lymphoproliferative malignancies in Wiskott-Aldrich and severe combined immune deficiency syndromes.In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York: Plenum Press (in press), 1983

    Google Scholar 

  32. Hanto DW, Frizzera G, Purtilo DT, Sakamoto K, Sullivan JL, Saemundsen AK, Klein G, Simmons RL, Najarian JS: Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus. Cancer Res 41:4253–4261, 1981

    Google Scholar 

  33. Purtilo DT: Epstein-Barr-virus-induced oncogenesis in immune deficient individuals. Lancet 1:300–303, 1980

    Google Scholar 

  34. Hanto DW, Frizzera G, Gajl-Peczalska KJ, Sakamoto KJ, Purtilo DT, Balfour HH, Simmons RL, Najarian JS: Epstein-Barr virus-induced B-cell lymphoma after renal transplantation: Acyclovir therapy and transition from polyclonal to monoclonal B-cell proliferation. N Engl J Med 306:913–918, 1982

    Google Scholar 

  35. Hanto DW, Frizzera G, Gajl-Peczalsk KJ, Purtilo DT, Simmons RL: Lymphoproliferative diseases in renal allograft recipients.In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York, Plenum Press, 1983

    Google Scholar 

  36. Bieber CP, Herberling RL, Jamieson SW, Oyer PE, Cleary M, Warnke R, Saemundsen A, Klein G, Henle W, Stinson EB: Lymphoma in cardiac transplant recipients associated with cyclosporin A, prednisone and anti-thymocyte globulin (ATG).In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York, Plenum Press (in press), 1983

    Google Scholar 

  37. Bieber CP, Pennock JL, Reitz BA: Lymphoma in Cyclosporin A treated non human primate allograft recipients in malignant lymphomas.In Malignant Lymphoma Etiology, Immunology, and Pathology Treatment, HS Kaplan, S Rosenberg (eds). New York, Academic Press, 1982, p 219

    Google Scholar 

  38. Shope T, Dechario D, Miller G: Malignant lymphoma in cotton-top marmosets after inoculation with Epstein-Barr virus. Proc Natl Acad Sci USA 70:2487–2491, 1973

    Google Scholar 

  39. Johnson DR, Levan G, Klein G, Nigida S, Wolfe L: Chromosomes and cell surface markers of marmoset lymphocytes and Epstein-Barr virus transformed marmoset cell lines. Cancer Gen Cytogenet 3:101–108, 1981

    Google Scholar 

  40. Sonnabend JA, Witkin SS, Purtilo RB, Purtilo DT: Why the syndrome of acquired immunodeficiency occurs among a subset of homosexual men.In Immune Deficiency and Cancer: Epstein-Barr Virus and Lymphoproliferative Malignancies, DT Purtilo (ed). New York, Plenum Press (in press), 1983

    Google Scholar 

  41. Curran JW, Evatt BL, Lawrence DN: Acquired immune deficiency syndrome: The past as prologue. Ann Intern Med 98:401–403, 1983

    Google Scholar 

  42. Elie R, Laroche AC, Arnoux E, Guerin J-M, Gerard P, Malebranche R, Seemayer TA, Dupuy J-M, Russo P, Lapp WS: Thymic dysplasia in acquired immunodeficiency syndrome. N Engl J Med 308:841, 1983

    Google Scholar 

  43. Seemayer TA, Lapp WS, Bolande RP: Thymic involution in murine graft-versus-host reaction: Epithelial injury mimicking human thymic dysplasia. Am J Pathol 88:119–134, 1977

    Google Scholar 

  44. Ziegler J, Drew WL, Miner RC, Mintz L, Rosenbaum E, Gershow J, Casavant C, Yamamoto K, Lennette ET, Greenspan J, Shillitoe E, Beckstead J: The outbreak of Burkitt's-like lymphoma in homosexual men. Lancet 2:631–633, 1982

    Google Scholar 

  45. Chaganti RSK, Jhanwar SC, Koziner B, Arlin Z, Mertelsmann R, Clarkson BD: Specific translocations characterize Burkitt's like lymphoma of homosexual men with the acquired immunodeficiency syndrome. Blood (in press), 1983

  46. Giraldo G, Beth E, Haguenau F. Herpes-type virus particles in tissue culture of Kaposi's sarcoma from different geographic regions. J Natl Cancer Inst 49:1509–1513, 1972

    Google Scholar 

  47. Drew WL, Conant MA, Miner RC, Huang ES, Ziegler JL, Groundwater JR, Gullett JH, Volberding P, Abrams DI, Mintz L: Cytomegalovirus and Kaposi's sarcoma in young homosexual men. Lancet 2:125–128, 1982

    Google Scholar 

  48. Fenoglio CM, Oster MW, Lo Gerfo P, Reynolds T, Edelson R, Patterson JAK, Madeiros E, McDougall JK: Kaposi's sarcoma following chemotherapy for testicular cancer in a homosexual man: Demonstration of cytomegalovirus RNA in sarcoma cells. Pathology 13:955–958, 1982

    Google Scholar 

  49. Costa J, Rabson AS: Generalized Kaposi's sarcoma is not a neoplasm. Lancet 1:58, 1983

    Google Scholar 

  50. Schreeder MT, Thompson SE, Hadler SC, Berquist KR, Zaidi A, Maynard JE, Ostrow D, Judson FN, Braff EH, Nylund T, Moore JN Jr, Gardner P, Doto IL, Reynolds G: Hepatitis B in homosexual men: Prevalence of infection and factors related to transmission. J Infect Dis 146:7–15, 1982

    Google Scholar 

  51. Deinhardt F, Gust ID: Viral hepatitis. Bull WHO 60:661–691, 1982

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine and Eppley Institute for Cancer Research and Allied Diseases, University of Nebraska Medical Center, 68105, Omaha, Nebraska

    David T. Purtilo MD & James Linder MD

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  1. David T. Purtilo MD
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  2. James Linder MD
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Purtilo, D.T., Linder, J. Oncological consequences of impaired immune surveillance against ubiquitous viruses. J Clin Immunol 3, 197–206 (1983). https://doi.org/10.1007/BF00915343

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