Abstract
The lymphocytes of two unrelated black individuals exhibited no immunofluorescent staining by a monoclonal antibody, OKT4, that reacts with T helper/inducer cells, but the lymphocytes reacted normally with four other monoclonal antibodies that identify T helper cells. Four first-degree relatives of these individuals were available for study. They had a normal proportion of OKT4+ lymphocytes but these cells had approximately half the normal number of OKT4 sites. This abnormality appears to be inherited as an autosomal recessive state.
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Karol, R.A., Eng, J., Dennison, D.K. et al. Hereditary abnormalities of the OKT4 human lymphocyte epitope in two families. J Clin Immunol 4, 71–74 (1984). https://doi.org/10.1007/BF00915290
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DOI: https://doi.org/10.1007/BF00915290