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Immunoglobulin genes: Rearrangement and translocation in human lymphoid malignancy

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References

  1. Malcom S, Barton P, Murphy C, Ferguson-Smith MA, Bentley DL, Rabbitts TH: Localization of human immunoglobulin κ light chain variable region genes to the short arm of chromosome 2 byin situ hybridization. Proc Natl Acad Sci USA 79:4957, 1982

    Google Scholar 

  2. Hieter PA, Max EE, Seidman JG, Maizel JV Jr, Leder P: Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell 22:197, 1980

    Google Scholar 

  3. Hieter PA, Maizel JV Jr, Leder P: Evolution of human immunoglobulin κ J region genes. J Biol Chem 257:1516, 1982

    Google Scholar 

  4. Hozumi N, Tonegawa S: Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. Proc Natl Acad Sci USA 73:3628, 1976

    Google Scholar 

  5. Brack C, Hirama M, Lenhard-Schuller R, Tonegawa S: A complete immunoglobulin gene is created by somatic recombination. Cell 15:1, 1978

    Google Scholar 

  6. Seidman JG, Leder P: The arrangement and rearrangement of antibody genes. Nature 276:790, 1978

    Google Scholar 

  7. Bently DL, Rabbitts TH: Human Vκ immunoglobulin gene number: Implications for the origin of antibody diversity. Cell 24:613, 1981

    Google Scholar 

  8. Seidman JG, Max EE, Leder P: A κ-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature 280:370, 1979

    Google Scholar 

  9. Max EE, Seidman JG, Leder P: Sequences of five potential recombination sites encoded close to an immunoglobulin k constant region gene. Proc Natl Acad Sci USA 76:3450, 1979

    Google Scholar 

  10. Sakano H, Huppi K, Heinrich G, Tonegawa S: Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature 280:288, 1979

    Google Scholar 

  11. Hieter PA, Hollis GF, Korsmeyer SJ, Waldmann TA, Leder P: Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes. Nature 294:536, 1981

    Google Scholar 

  12. McBride OW, Hieter PA, Hollis GF, Swan D, Otey MC, Leder P: Chromosomal location of human kappa and lambda immunoglobulin light chain constant region genes. J Exp Med 155:1480, 1982

    Google Scholar 

  13. Taub RA, Hollis GF, Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P: The variable amplification of immunoglobulin lambda light chain genes in human populations. Nature 304:172, 1983

    Google Scholar 

  14. Korsmeyer SJ, Hieter PA, Sharrow SO, Goldman CK, Leder P, Waldmann TA: Normal human B-cells display ordered light-chain gene rearrangements and deletions. J Exp Med 156:975, 1982

    Google Scholar 

  15. Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P: Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B-cells. Nature 290:368, 1981

    Google Scholar 

  16. Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P: Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci USA 78:7096, 1981

    Google Scholar 

  17. Early P, Huang H, Davis M, Calame K, Hood L: An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH. Cell 19:981, 1980

    Google Scholar 

  18. Sakano H, Kurosawa Y, Weigert M, Tonegawa S: Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature 290:562, 1981

    Google Scholar 

  19. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P: Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes. Cell 26:583, 1981

    Google Scholar 

  20. Siebenlist U, Ravetch JV, Korsmeyer SJ, Waldmann TA, Leder P: Human immunoglobulin D segments encoded in tandem multigenic families. Nature 294:631

  21. Knapp MR, Liu C-P, Newell N, Ward RB, Tucker PW, Strober S, Blattner F: Simultaneous expression of immunoglobulin μ and δ heavy chains by a cloned B-cell lymphoma: A single copy of the VH gene is shared by two adjacent CH genes. Proc Natl Acad Sci USA 79:2996, 1982

    Google Scholar 

  22. Moore KW, Rogers H, Hunkapiller T, Early P, Nottenburg C, Weissman I, Basin H, Wall R, Hood L: Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms. Proc Natl Acad Sci USA 78:1800, 1982

    Google Scholar 

  23. Davis MM, Kim SK, Hood LE: DNA sequences mediating class switching in α-immunoglobulins. Science 209:1360, 1980

    Google Scholar 

  24. Kataoka T, Miyata T, Honjo T: Repetitive sequences in class switch recombination regions of immunoglobulin heavy chain genes. Cell 23:357, 1981

    Google Scholar 

  25. Marcu KB, Lang RB, Stanton LW, Harris LJ: A model for the molecular requirements of immunoglobulin heavy chain class switching. Nature 298:87, 1982

    Google Scholar 

  26. Ravetch JV, Kirsch IR, Leder P: Evolutionary approach to the question of immunoglobulin heavy chain switching: Evidence from cloned human and mouse genes. Proc Natl Acad Sci USA 77:6734, 1980

    Google Scholar 

  27. Rabbitts TH, Forster A, Milstein CP: Human immunoglobulin heavy chain genes: evolutionary comparisons of Cμ, Cδ, and Cγ, genes and associated switch sequences. Nucl Acids Res 9:4509, 1981

    Google Scholar 

  28. Chessells JM, Hardisty RM, Rapson NT, Greaves MF: Acute lymphoblastic leukemia in children: classification and prognosis. Lancet 2:1307, 1977

    Google Scholar 

  29. Korsmeyer SJ, Arnold A, Bakhshi A, Ravetch JV, Siebenlist U, Hieter PA, Sharrow SO, LeBien TW, Kersey JH, Poplack DG, Leder P, Waldmann TA: Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T-cell and B-cell precursor origins. J Clin Invest 71:301, 1983

    Google Scholar 

  30. Alt FW, Enea V, Bothwell ALM, Baltimore D: Activity of multiple light-chain genes in murine myeloma cells producing a single, functional light chain. Cell 21:1, 1980

    Google Scholar 

  31. Coleclough C, Perry RP, Karjalainen K, Weigert M: Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression. Nature 290:372, 1981

    Google Scholar 

  32. Barr RD, Fialkow PJ: Clonal origin of chronic myelocytic leukemia. N Engl J Med 289:307, 1973

    Google Scholar 

  33. LeBien TW, Hozier J, Minowada J, Kersey JH: Origin of chronic myelocytic leukemia in a precursor of Pre-B Lymphocytes. N Engl J Med 301:144, 1979

    Google Scholar 

  34. Minowada J, Tsubota T, Greaves M: A non-T, non-B human leukemia cell line (Nalm-1): Establishment of the cell line and presence of leukemia-associated antigens. J Natl Cancer Inst 59:83, 1977

    Google Scholar 

  35. Volger LB, Crist WM, Vinson PC, Sarrif A, Brattain MG, Coleman MS: Philadelphia-chromosome-positive pre-B cell leukemia presenting as blast crisis of chronic myelogenous leukemia. Blood 54:1164, 1979

    Google Scholar 

  36. Bakhshi A, Minowada J, Arnold A, Cossman J, Jensen J, Whang-Peng J, Waldmann TA, Korsmeyer SJ: Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. N Engl J Med 309:826, 1983

    Google Scholar 

  37. Ford AM, Molgaard HV, Greaves MF, Gould HJ: Immunoglobulin gene organization and expression in hematopoietic stem cell leukemia. Embo J 2:997, 1983

    Google Scholar 

  38. Golomb HM, Catovsky D, Golde DW: Hairy cell leukemia: A clinical review based on 71 cases. Ann Intern Med 89:677, 1978

    Google Scholar 

  39. Jansen J, LeBien TW, Kersey JD: The phenotype of neoplastic cells of hairy cell leukemia studied with monoclonal antibodies. Blood 59:609, 1982

    Google Scholar 

  40. Scheinberg M, Brenner AI, Sullivan AL, Cathcort ES, Katoyama I: The heterogeneity of leukemia reticuloendotheliosis “hairy cell leukemia.” Evidence for its monocytic origin. Cancer 37:1302, 1976

    Google Scholar 

  41. Saxon A, Stevens RH, Golde DW: Lymphocyte variant of hairy cell leukemia. Ann Intern Med 88:323, 1978

    Google Scholar 

  42. Guglielmi P, Preud'homme JL, Flandrin G: Phenotypic change of phytohemagglutin stimulated hairy cells. Nature 286:166, 1980

    Google Scholar 

  43. Korsmeyer SJ, Green WC, Cossman H, Hsu SM, Neckers LM, Marshall SL, Jensen JP, Bakhshi A, Leonard WJ, Jaffe ES, Waldmann TA: Rearrangements and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proc Natl Acad Sci USA 80:4522, 1983

    Google Scholar 

  44. Uchiyama T, Broder S, Waldmann TA: A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T-cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac(+) cells. J Immunol 126:1393, 1981

    Google Scholar 

  45. Uchiyama T, Nelson DL, Fleisher TA, Waldmann TA: A monoclonal antibody (anti-Tac) reactive with activated and functionally mature T-cells. II. Expression of Tac antigen on activated cytotoxic killer T-cells, suppressor cells, and on one of two types of helper T-cells. J Immunol 126:1398, 1981

    Google Scholar 

  46. Leonard WJ, Depper JM, Uchiyama T, Smith KA, Waldmann TA, Greene WC: A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor. Nature 300:267, 1982

    Google Scholar 

  47. Howard M, Kessler S, Chused T, Paul W: Long term culture of normal mouse B-lymphocytes. Proc Natl Acad Sci USA 78:5788, 1981

    Google Scholar 

  48. Leibson HJ, Marrack P, Kappler J: B-cell helper factors. I. Requirement for both interleukin-2 and another 40,000 molecular weight factor. J Immunol 129:1398, 1982

    Google Scholar 

  49. Levy R, Warnke R, Dorfman RF, Haimovich J: The monoclonality of human B-cell lymphomas. J Exp Med 145:1014, 1977

    Google Scholar 

  50. Rowley JD, Fukuhara S: Chromosome studies in non-Hodgkins's lymphomas. Sem Oncol 7:255, 1980

    Google Scholar 

  51. Fialkow PJ, Klein E, Klein G, Clifford P, Singh S: Immunoglobulin and glucose-6-phosphate dehydrogenase as markers of cellular origin in Burkitt lymphoma. J Exp Med 138:89, 1973

    Google Scholar 

  52. Arnold A, Cossman J, Jaffe E, Waldmann TA, Korsmeyer SJ: Immunoglobulin gene rearrangement as a marker for monoclonality in lymphoid neoplasms. Clin Res 31:402A, 1983

    Google Scholar 

  53. Rowley JD: Chromosome abnormalities in cancer. Cancer Genet Cytogenet 2:175, 1980

    Google Scholar 

  54. Croce CM, Shadner M, Martinis J, Cicurel L, D'Ancona GG, Dolby TW, Koprowski H: Chromosomal location of the genes for human immunoglobulin heavy chains. Proc Natl Acad Sci USA 76:3416, 1979

    Google Scholar 

  55. Kirsch IR, Morton CC, Nakahara K, Leder P: Human immunoglobulin heavy chain genes map to a region of translocation in malignant B-lymphocytes. Science 216:301, 1982

    Google Scholar 

  56. Lenoir GM, Preud'homme JL, Bernheim A, Berger R: Correlations between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma. Nature 298:474, 1982

    Google Scholar 

  57. Bishop JM: Cancer genes come of age. Cell 32:1018, 1983

    Google Scholar 

  58. Hayward WS, Nell BG, Astrin SM: Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290:475, 1981

    Google Scholar 

  59. Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, Aaronson S, Leder P: Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt's lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 79:7837, 1982

    Google Scholar 

  60. Nishikura K, Ar-Rushdi A, Erickson J, Watt R, Rovera G, Croce CM: Differential expression of the normal and of the translocated human c-myc oncogenes in B-cells. Proc Natl Acad Sci USA 80:4822, 1983

    Google Scholar 

  61. Erikson J, Finan J, Nowell PC, Croce CM: Translocation of immunoglobulin VH genes in Burkitt lymphoma. Proc Natl Acad Sci USA 79:5611, 1982

    Google Scholar 

  62. Gillies SD, Morrison SL, Qi VT, Tonegawa S: A tissue specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy-chain gene. Cell 33:717, 1983

    Google Scholar 

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  1. Metabolism Branch, National Cancer Institute National Institutes of Health, 20205, Bethesda, Maryland

    Stanley J. Korsmeyer & Thomas A. Waldmann

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  1. Stanley J. Korsmeyer
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Korsmeyer, S.J., Waldmann, T.A. Immunoglobulin genes: Rearrangement and translocation in human lymphoid malignancy. J Clin Immunol 4, 1–11 (1984). https://doi.org/10.1007/BF00915280

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