Journal of Clinical Immunology

, Volume 4, Issue 2, pp 98–107 | Cite as

Changes in immunoregulatory lymphocyte populations in patients with histoplasmosis

  • Donald G. Payan
  • L. Joseph Wheat
  • Zackarie Brahmi
  • Stephen Ip
  • W. Peter Hansen
  • Robert A. Hoffman
  • Kathleen Healey
  • Robert H. Rubin
Original Articles


Circulating T-lymphocyte subpopulations were enumerated in 65 patients with histoplasmosis and correlated with the different clinical manifestations of the disease. Acute pulmonary histoplasmosis, rheumatologic, disseminated, and chronic inflammatory manifestations of histoplasmosis were all associated with a significant elevation above normal of OKT8+ (suppressor-cytotoxic) lymphocytes and a significantly lower than normal OKT4+ (helper-inducer)-lymphocyte to OKT8+-lymphocyte ratio. In contrast, cavitary disease was associated with an increase in OKT4+ lymphocytes, a decrease in OKT8+ lymphocytes, and a higher than normal OKT4/OKT8 ratio. Clinical recovery was associated with normalization of these values. Functional activity determined by coculture techniques correlated closely with T-lymphocyte subset measurements. These distinct subset abnormalities may help monitor immunological aspects of disease activity.

Key words

Histoplasmosis lymphocytes subsets monoclonal antibodies 


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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Donald G. Payan
    • 1
  • L. Joseph Wheat
    • 2
  • Zackarie Brahmi
    • 2
  • Stephen Ip
    • 3
  • W. Peter Hansen
    • 3
  • Robert A. Hoffman
    • 3
  • Kathleen Healey
    • 3
  • Robert H. Rubin
    • 1
  1. 1.Infectious Disease Unit and the Medical Service of the Massachusetts General Hospital and the Department of MedicineHarvard Medical SchoolBoston
  2. 2.Infectious Disease Service and the Departments of Medicine and Microbiology of the Indiana University Medical CenterIndianapolis
  3. 3.Ortho Diagnostic Systems, Inc.Westwood

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