α, Β-Disubstitutedα-acylamino carboxylic acids Communication 3. 2,2-bisacylamino-3-halopropionic acids

  • O. V. Kil'disheva
  • V. V. Shokina
  • I. L. Knuniants
Organic and Biological Chemistry
  • 19 Downloads

Summary

  1. 1.

    Halopyruvic acids condense with nitriles with formation of 2,2-bisacylamino-3-halopropionic acids.

     
  2. 2.

    2,2-Bisacylamino-3-halopropionic acids were converted into a) new serine derivatives containing a 2-(acylamino) substituent, and b) 4-(acylamino)-2-aryl(or alkyl)-4-(halomethyl)-2-oxazolin-o-ones.

     
  3. 3.

    The oxazolinones obtained were found to be powerful acylating agents. Acylation with these oxazolinones is generally associated with a secondary reaction in which the acylation product is converted into an (acylamino) oxazoline. By the hydrolysis of 4-acetamido-4-(chloromethyl)-2-methyl-2-oxazolin-5-one we obtained 2-acetamido-2-amino-3-chloropropionic acid, which is a new compound.

     

Keywords

Hydrolysis Serine Nitrile Carboxylic Acid Secondary Reaction 

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Literature cited

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Copyright information

© Consultants Bureau Inc. 1959

Authors and Affiliations

  • O. V. Kil'disheva
    • 1
  • V. V. Shokina
    • 1
  • I. L. Knuniants
    • 1
  1. 1.Institute of Heteroorganic Compounds of the Academy of Sciences of the USSRUSSR

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