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α, Β-Disubstitutedα-acylamino carboxylic acids Communication 3. 2,2-bisacylamino-3-halopropionic acids

  • O. V. Kil'disheva
  • V. V. Shokina
  • I. L. Knuniants
Organic and Biological Chemistry

Summary

  1. 1.

    Halopyruvic acids condense with nitriles with formation of 2,2-bisacylamino-3-halopropionic acids.

     
  2. 2.

    2,2-Bisacylamino-3-halopropionic acids were converted into a) new serine derivatives containing a 2-(acylamino) substituent, and b) 4-(acylamino)-2-aryl(or alkyl)-4-(halomethyl)-2-oxazolin-o-ones.

     
  3. 3.

    The oxazolinones obtained were found to be powerful acylating agents. Acylation with these oxazolinones is generally associated with a secondary reaction in which the acylation product is converted into an (acylamino) oxazoline. By the hydrolysis of 4-acetamido-4-(chloromethyl)-2-methyl-2-oxazolin-5-one we obtained 2-acetamido-2-amino-3-chloropropionic acid, which is a new compound.

     

Keywords

Hydrolysis Serine Nitrile Carboxylic Acid Secondary Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

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    O. V. Kil'disheva, M. G. Lin'kova, Z. V. Benevolenskaia, and I. L. Knuniants, Bull. Acad. Sci. USSR, Div. Chem. Sci. 1956, 834.Google Scholar
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    O. V. Kil'disheva, M. G. Lin'kova, and I. L. Knuniants, Bull. Acad. Sci. USSR, Div. Chem. Sci. 1955, 271.Google Scholar
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    O. V. Kil'disheva, M. G. Lin'kova, and I. L. Knuniants, Bull Acad. Sci. USSR, Div. Chem. Sci. 1955, 282.Google Scholar

Copyright information

© Consultants Bureau Inc. 1959

Authors and Affiliations

  • O. V. Kil'disheva
    • 1
  • V. V. Shokina
    • 1
  • I. L. Knuniants
    • 1
  1. 1.Institute of Heteroorganic Compounds of the Academy of Sciences of the USSRUSSR

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