, Volume 3, Issue 3, pp 243–251 | Cite as

Acute induction of joint inflammation in the rat by Poly I · Poly C

  • Michael Yaron
  • Mimi Baratz
  • Ilana Yaron
  • Uriel Zor
Original Articles


Intraarticular injection of interferon inducer, double-stranded polyinosinate-polycytidylate (Poly I · C) caused acute synovitis in rats. This acute inflammatory response was accompanied by an increased concentration of prostaglandin E (PGE) in the synovial tissue. Double-stranded polyadenylate-polyuridylate (Poly A · Poly U) was less potent than Poly I · Poly C in inducing synovitis and increasing PGE concentration, while single-stranded polyinosinate (Poly I) or polycytidylate (Poly C) were inactive in these respects. Intraarticular injection of partially purified mouse fibroblast interferon also induced synovial inflammation. The present results suggest that interferon may be a mediator of viral inflammatory responses.


Public Health Internal Medicine Inflammatory Response Interferon Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Smith, J. W., andJ. P. Sanford. 1967. Viral arthritis.Ann. Intern. Med. 67:651–659.Google Scholar
  2. 2.
    Webb, F. W., R. Bluestone, L. S. Goldberg et al. 1973. Experimental viral arthritis induced with herpes simplex.Arthritis Rheum. 16:241–250.Google Scholar
  3. 3.
    Yaron, M., I. Yaron, O. Smetana et al. 1976. Hyaluronic acid production by human synovial fibroblasts: Effect of polyinosinic-polycytidylic acid (Poly I:C) and interferon.Arthritis Rheum. 19:1315–1320.Google Scholar
  4. 4.
    Yaron, M., I.Yaron, C.Wiletzki et al. 1978. Interrelationship between stimulation of prostaglandin E and hyaluronate production by Poly (I) · Poly (C) and interferon in synovial fibroblast culture.Arthritis Rheum. (in press).Google Scholar
  5. 5.
    Yaron, M., I. Yaron, D. Gurari-Rotman. 1977. Stimulation of prostaglandin E production in cultured human fibroblasts by Poly (I) · Poly (C) and human interferon.Nature 267:457–459.Google Scholar
  6. 6.
    Dirosa, M., J. P. Giroud, andD. A. Willoughby. 1971. Studies of the mediators of the acute inflammatory response induced in rats in different sites by carrageenin and turpentine.J. Pathol. 104:15–29.Google Scholar
  7. 7.
    Floman, Y., E. Okon, andU. Zor. 1977. The role of prostaglandins in experimental arthritis in the rat.Clin. Orthop. Rel. Res. 125:214–220.Google Scholar
  8. 8.
    Lindahl, P., P. Leary, andI. Gresser. 1972. Enhancement by interferon of the specific cytotoxicity of sensitized lymphocytes.Proc. Natl. Acad. Sci. U.S.A. 69:721–725.Google Scholar
  9. 9.
    Huang, K. Y., R. M. Donahoe, F. B. Gordon et al. 1971. Enhancement of phagocytosis by interferon containing preparations.Infect. Immun. 4:581–588.Google Scholar
  10. 10.
    Johnson, H. M., andS. Baron. 1976. Interferon: Effects on the immune response and the mechanism of activation of the cellular response.CRC Crit. Rev. Biochem. 1976:203–215.Google Scholar
  11. 11.
    Koltai, M., andE. Mécs. 1973. Inhibition of the acute inflammatory response by interferon inducers.Nature 242:525–526.Google Scholar
  12. 12.
    Field, A. K., A. A. Tytell, andG. P. Lampson et al. 1967. Inducers of interferon and host resistance II. Multistranded synthetic polynucleotide complexes.Proc. Natl. Acad. Sci. U.S.A. 58:1004–1010.Google Scholar
  13. 13.
    Ferreira, S. H., S. Moncada, andJ. R. Vane. 1974.In Prostaglandin Synthetase Inhibitors. J. H. Robinson, J. R. Vane, editors. Raven Press, New York, pp. 175–187.Google Scholar
  14. 14.
    Zurier, R. B., andM. Ballos. 1973. Prostaglandin e1 suppression of adjuvant arthritis.Arthritis Rheum. 16:251–258.Google Scholar
  15. 15.
    Yaron, M., andC. W. Castor. 1969. Leukocyte-connective tissue cell interaction. I. Stimulation of hyaluronate synthesis by live and dead leukocytes.Arthritis Rheum. 12:365–374.Google Scholar
  16. 16.
    Yaron, M., I. Yaron, andD. Allalouf. 1971. Effect of some anti-inflammatory drugs on fibroblast-leukocyte interaction in vitro.Ann. Rheum. Dis. 30:613–619.Google Scholar
  17. 17.
    Yanez, J. E., G. R. Thompson, W. M. Mikkelson et al. 1966. Rubella arthritis.Ann. Intern. Med. 64:772–778.Google Scholar
  18. 18.
    Wilkes, R. M., J. P. Simsarian, H. E. Hopps et al. 1973. Virologic studies on rheumatoid arthritis.Arthritis Rheum. 16:446–455.Google Scholar

Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Michael Yaron
    • 1
    • 2
  • Mimi Baratz
    • 1
    • 2
  • Ilana Yaron
    • 1
    • 2
  • Uriel Zor
    • 1
    • 2
  1. 1.Arthur and Nela Rubinstein Arthritis Research Unit, Departments of Physical Medicine and Rheumatology and Pathology, Rokach and Ichilov Medical CenterTel-Aviv UniversityIsrael
  2. 2.Sackler Medical School, and Department of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael

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