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Inflammation

, Volume 3, Issue 3, pp 243–251 | Cite as

Acute induction of joint inflammation in the rat by Poly I · Poly C

  • Michael Yaron
  • Mimi Baratz
  • Ilana Yaron
  • Uriel Zor
Original Articles

Abstract

Intraarticular injection of interferon inducer, double-stranded polyinosinate-polycytidylate (Poly I · C) caused acute synovitis in rats. This acute inflammatory response was accompanied by an increased concentration of prostaglandin E (PGE) in the synovial tissue. Double-stranded polyadenylate-polyuridylate (Poly A · Poly U) was less potent than Poly I · Poly C in inducing synovitis and increasing PGE concentration, while single-stranded polyinosinate (Poly I) or polycytidylate (Poly C) were inactive in these respects. Intraarticular injection of partially purified mouse fibroblast interferon also induced synovial inflammation. The present results suggest that interferon may be a mediator of viral inflammatory responses.

Keywords

Public Health Internal Medicine Inflammatory Response Interferon Prostaglandin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1979

Authors and Affiliations

  • Michael Yaron
    • 1
    • 2
  • Mimi Baratz
    • 1
    • 2
  • Ilana Yaron
    • 1
    • 2
  • Uriel Zor
    • 1
    • 2
  1. 1.Arthur and Nela Rubinstein Arthritis Research Unit, Departments of Physical Medicine and Rheumatology and Pathology, Rokach and Ichilov Medical CenterTel-Aviv UniversityIsrael
  2. 2.Sackler Medical School, and Department of Hormone ResearchThe Weizmann Institute of ScienceRehovotIsrael

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