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Inflammation

, Volume 4, Issue 2, pp 205–213 | Cite as

Induction of cell infiltration and acid hydrolase release into the peritoneal cavity of mice

  • A. P. Green
  • F. Mangan
  • J. E. Ormerod
Original Articles

Abstract

An injection of thioglycollate into the peritoneal cavity of mice produced a peak of exudate at 4 h, a peak of total leukocytes at 24 h when the predominant cell was the polymorphonuclear neutrophil, and a secondary macrophage phase beginning 2–3 days after thioglycollate. The release ofN-acetylglucosaminidase (EC 3.2.1.30) into the peritoneal fluid paralleled the macrophage phase. The amount of enzyme released was related to the dose of thioglycollate. Neither zymosan (400μg) nor endotoxin (30μg) produced a marked inflammatory response when injected into the peritoneal cavity.

Keywords

Public Health Internal Medicine Inflammatory Response Peritoneal Cavity Cell Infiltration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • A. P. Green
    • 1
  • F. Mangan
    • 1
  • J. E. Ormerod
    • 1
  1. 1.Beecham Pharmaceutical, Research DivisionMedicinal Research CentreHarlowEngland

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