, Volume 4, Issue 2, pp 205–213 | Cite as

Induction of cell infiltration and acid hydrolase release into the peritoneal cavity of mice

  • A. P. Green
  • F. Mangan
  • J. E. Ormerod
Original Articles


An injection of thioglycollate into the peritoneal cavity of mice produced a peak of exudate at 4 h, a peak of total leukocytes at 24 h when the predominant cell was the polymorphonuclear neutrophil, and a secondary macrophage phase beginning 2–3 days after thioglycollate. The release ofN-acetylglucosaminidase (EC into the peritoneal fluid paralleled the macrophage phase. The amount of enzyme released was related to the dose of thioglycollate. Neither zymosan (400μg) nor endotoxin (30μg) produced a marked inflammatory response when injected into the peritoneal cavity.


Public Health Internal Medicine Inflammatory Response Peritoneal Cavity Cell Infiltration 
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  1. 1.
    Ringrose, P. S., M. A. Parr, andM. Mclaren. 1975.Biochem. Pharmacol. 24:607.Google Scholar
  2. 2.
    Gordon, S., J. C. Unkeless, andZ. A. Cohn. 1974.J. Exp. Med. 140:995.Google Scholar
  3. 3.
    Edelson, P. J., andC. Erbs.J. Immunol. 1978.120:1532.Google Scholar
  4. 4.
    Spector, W. G. 1974.In The Inflammatory Process, 2nd Ed. (Eds.) B. W. Zureifach, L. Grant, and A. C. Allison, editors. Academic Press, New York. 277.Google Scholar
  5. 5.
    Hancock, P. M., M. W. Hill, andN. W. Johnson. 1978.Br. J. Exp. Pathol. 59:128.Google Scholar
  6. 6.
    Dy, M., M. Debray-Sachs, P. Kamoun, andJ. Hamburger. 1978.Biomedicine. 29:167.Google Scholar
  7. 7.
    Davies, G. E., andA. Thompson. 1975.J. Pathol. 115:17.Google Scholar
  8. 8.
    Weissmann, G., P. Dukor, andR. B. Zurier. 1971.Nature New Biol. 231:131.Google Scholar
  9. 9.
    Schnyder, J., andM. Baggiolini. 1978.J. Exp. Med. 148:435.Google Scholar
  10. 10.
    Arrigoni-Martelli, E., E. Bramm, andL. Binderup. 1976.Pharmacology. 14:405.Google Scholar
  11. 11.
    Giri, S. N. B. Goshi, andS. A. Peoples. 1975.Clin. Exp. Pharm. Physiol. 2:193.Google Scholar
  12. 12.
    Arrigoni-Martelli, E., andA. Restelli. 1972.Eur. J. Pharmacol. 19:191.Google Scholar
  13. 13.
    Schnyder, J., andM. Baggiolini. 1978.J. Exp. Med. 148:1449.Google Scholar
  14. 14.
    Schorlemmer, H. V., P. Davies, W. Hylton, M. Gugig, andA. C. Allison. 1977.Br. J. Exp. Pathol. 58:315.Google Scholar
  15. 15.
    Keystone, E. C., H. V. Schorlemmer, C. Pope, andA. C. Allison. 1977.Arthritis Rheum. 20:1396.Google Scholar
  16. 16.
    Moeller, G. R., L. Terry, andR. Snyderman. 1978.J. Immunol. 120:116.Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • A. P. Green
    • 1
  • F. Mangan
    • 1
  • J. E. Ormerod
    • 1
  1. 1.Beecham Pharmaceutical, Research DivisionMedicinal Research CentreHarlowEngland

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