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IgA paraprotein inhibition of human neutrophil chemotaxis reduced activity following treatment with IgA-specific protease fromNeisseria gonorrhoeae

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Abstract

Removal of the Fc region of human IgA M components by treatment with IgA-specific protease fromNeisseria gonorrhoeae reduces the neutrophil chemotactic inhibitory activity associated with IgA M components. This observation, along with the failure of an IgA halfmer paraprotein to inhibit neutrophil chemotaxis, emphasizes the importance of the IgA Fc region in the inhibition of neutrophil chemotaxis by IgA M components.

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Authors and Affiliations

  1. Departments of Medicine and Microbiology, University of New Mexico, Albuquerque, New Mexico

    Dennis E. Van Epps & Ralph C. Williams Jr.

  2. Department of Medicine, Tufts New England Medical School, Boston, Massachusetts

    Andrew Plaut

  3. Department of Medicine, Dartmouth-Hitchcock Medical Center, Hanover, New Hampshire

    George M. Bernier

Authors
  1. Dennis E. Van Epps
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  2. Andrew Plaut
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  3. George M. Bernier
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  4. Ralph C. Williams Jr.
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Van Epps, D.E., Plaut, A., Bernier, G.M. et al. IgA paraprotein inhibition of human neutrophil chemotaxis reduced activity following treatment with IgA-specific protease fromNeisseria gonorrhoeae . Inflammation 4, 137–144 (1980). https://doi.org/10.1007/BF00914160

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  • DOI: https://doi.org/10.1007/BF00914160

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