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Use of various activated esters in the synthesis of polypeptides of regular structure and their comparative evaluation

  • Organic and Biological Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A number of polypeptides of regular structure have been synthesized by the method of activated esters (p-nitrophenyl, 2,4,6-trichlorophenyl, 2,4,5-trichlorophenyl, pentachlorophenyl, pentafluorophenyl, 3-hydroxypyridine, 8-hydroxyquinoline, and hydroxysuccinimide).

  2. 2.

    A comparative evaluation of activated esters in the synthesis of polypeptides of regular structure is given.

  3. 3.

    Pentafluorophenyl, 3-hydroxypyridine, 8-hydroxyquinoline, 2,4,5-trichlorophenyl, and hydroxysuccinimide activated esters are used for the first time in the synthesis of polypeptides of regular structure.

  4. 4.

    Models of the collagen structure: (gly-pro-hypro)n, (gly-hypro-hypro)n, and (gly-ala-hypro)n have been synthesized and the obtained polypeptides have been shown to be isomorphous with collagen.

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Authors and Affiliations

  1. Institute of Molecular Biology, Academy of Sciences of the USSR, USSR

    V. A. Shibnev, T. P. Chuvaeva & K. T. Poroshin

  2. Institute of Chemistry, Academy of Sciences of the Tadzhik USSR, USSR

    V. A. Shibnev, T. P. Chuvaeva & K. T. Poroshin

Authors
  1. V. A. Shibnev
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  2. T. P. Chuvaeva
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  3. K. T. Poroshin
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 1, pp. 121–129, January, 1970.

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Shibnev, V.A., Chuvaeva, T.P. & Poroshin, K.T. Use of various activated esters in the synthesis of polypeptides of regular structure and their comparative evaluation. Russ Chem Bull 19, 111–117 (1970). https://doi.org/10.1007/BF00913934

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  • DOI: https://doi.org/10.1007/BF00913934

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