Synthesis of active esters of tripeptides containing Nɛ-tosyl-L-lysine and their polymerization

  • V. A. Shibnev
  • V. S. Grechishko
  • K. T. Poroshin
Organic and Biological Chemistry
  • 19 Downloads

Conclusions

  1. 1.

    Chromatographically pure p-nitrophenyl and 2,4,6-trichlorophenyl esters of the tripeptides glycyl-prolyl-Nɛ-tosyl-lysine and glycyl-(Nɛ-tosyl)-lysyl-(Nɛ-tosyl)-lysine were synthesized by the mixed anhydride method.

     
  2. 2.

    Polypeptides of regular structure with sequence [glycyl-prolyl-(Nɛ-tosyl)-lysyl]n and [glycyl-(Nɛ-tosyl)-lysyl-(NNɛ-tosyl)-lysyl]n, with mol.wt. 10,000 and 7000 respectively, were obtained.

     

Keywords

Polymerization Ester Lysine Polypeptide Anhydride 

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Literature cited

  1. 1.
    R. B. Khesin, Uspekhi sovr. Mol.,59, 12 (1965).Google Scholar
  2. 2.
    D. F. De Tar, W. Honsberg, U. Honsberg, A. Wieland, M. Gouge, H. Bach, A. Tahara, W. S. Brinigar, and F. F. Rogers, Jr., J. Amer. Chem. Soc.,85, 2873 (1963).Google Scholar
  3. 3.
    J. Kovacs and A. Kapoor, J. Amer. Chem. Soc.,87, 118 (1965); V. A. Shibnev, K. T. Poroshin, V. S. Grechishko, A. V. Lisovenko, and T. P. Chuvaeva, Dokl. AN Tadzh SSR,9, No. 7, 16 (1966).Google Scholar
  4. 4.
    V. A. Shibnev, T. P. Chuvaeva, and K. T. Poroshin, Izv. AN SSSR, Ser. khim.,1967, 954.Google Scholar
  5. 5.
    V. A. Shibnev, K. M. Dyumaev, T. P. Chuvaeva, L. D. Smirnov, and K. T. Poroshin, Izv. AN SSSR, Ser. khim.,1967, 1634.Google Scholar
  6. 6.
    V. A. Shibnev, K. T. Poroshin, and V. S. Grechishko, Izv. AN SSSR, Ser. Khim.,1966, 1493.Google Scholar
  7. 7.
    G. Kupryszewski, Rocznik. Chem.,35, 595 (1961).Google Scholar
  8. 8.
    R. Roeske, F. H. C. Stewart, R. J. Stedman, and V. du Vigneaud, J. Amer. Chem. Soc.,78, 5883 (1956).Google Scholar
  9. 9.
    V. A. Shibnev, T. D. Kozarenko, and K. T. Poroshin, Izv. AN SSSR, Otd. khim. n.,1960, 1500.Google Scholar
  10. 10.
    M. Bodanszky, J. Meienhofer, and V. du Vigneaud, J. Amer. Chem. Soc.,82, 3195 (1960).Google Scholar

Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • V. A. Shibnev
    • 1
    • 2
  • V. S. Grechishko
    • 1
    • 2
  • K. T. Poroshin
    • 1
    • 2
  1. 1.Institute of Biological PhysicsAcademy of Sciences of the USSRUSSR
  2. 2.Institute of ChemistryAcademy of Sciences of the TadzhSSRUSSR

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