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Synthesis and reactivity studies of several derivatives of p-[DI(2-chloropropyl)amino]phenylacetic acid

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A new method for synthesizing p-[di(2-chloropropyl)amino]phenylacetic acid has been developed.

  2. 2.

    A series of new derivatives of p-[di(2-chloropropyl)amino]phenylacetic acid has been synthesized: p-[di(2-chloropropyl)amino]benzyl cyanide, p-[di(2-chloropropyl)amino]phenylacetamide, andα,α-di{p-[di(2-chloropropyl)amino]phenylacetamido}propionic acid.

  3. 3.

    The rate of hydrolysis of the chlorine atom of chloropropylphenylacetic acid derivatives is significantly higher than the comparable rates of the analogous chloroethylaminophenylacetic acid derivatives.

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Literature cited

  1. I. L. Knunyants, N. E. Golubeva, and O. V. Kil'disheva, DAN SSSR,132, 836 (1960).

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  2. K. I. Karpavichyus, V. V. Kutorga, and B. I. Damartskis, Proceedings of the Seventh Onchological Conference [in Russian], Vilnius (1964), p. 14.

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  4. A. Purenas and J. Degutis, Kauno Politechnikos Instituto Darbai,6, 191 (1957); J. Degutis, Disertacija, Kaunas (1957).

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Authors and Affiliations

  1. Scientific Research Institute for Onchology of the Public Health Ministry of the LitSSR, USSR

    K. I. Karpavichus, S. P. Zdanauskas, G. I. Prasmitskene, O. V. Kil'disheva & I. L. Knunyants

  2. Institute for Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    K. I. Karpavichus, S. P. Zdanauskas, G. I. Prasmitskene, O. V. Kil'disheva & I. L. Knunyants

Authors
  1. K. I. Karpavichus
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  2. S. P. Zdanauskas
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  3. G. I. Prasmitskene
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  4. O. V. Kil'disheva
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  5. I. L. Knunyants
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 649–650, March, 1968.

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Karpavichus, K.I., Zdanauskas, S.P., Prasmitskene, G.I. et al. Synthesis and reactivity studies of several derivatives of p-[DI(2-chloropropyl)amino]phenylacetic acid. Russ Chem Bull 17, 625–626 (1968). https://doi.org/10.1007/BF00911625

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  • DOI: https://doi.org/10.1007/BF00911625

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