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A new method for the synthesis of macrocyclic compounds

Communication 7. Preparation of macrocyclic ketolactones by intramolecular acylation

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A new method for the synthesis of macrocyclic ketolactones containing a thiophene ring has been developed.

  2. 2.

    The reductive desulfuration of macrocyclic ketolactones containing a thiophene ring has given ketoalkanolides, in particular that with a 14-membered ring the structure of which is close to that of the cyclic fragment of the natural macrolide antibiotics.

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Authors and Affiliations

  1. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, USSR

    S. Z. Taits, F. D. Alashev & Ya. L. Gol'dfarb

Authors
  1. S. Z. Taits
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  2. F. D. Alashev
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  3. Ya. L. Gol'dfarb
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 566–572, March, 1968.

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Taits, S.Z., Alashev, F.D. & Gol'dfarb, Y.L. A new method for the synthesis of macrocyclic compounds. Russ Chem Bull 17, 550–554 (1968). https://doi.org/10.1007/BF00911609

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  • DOI: https://doi.org/10.1007/BF00911609

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