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Inflammation

, Volume 6, Issue 1, pp 31–38 | Cite as

Modulation of human lymphocyte transformation by bacterial products and leukocyte lysates

  • M. N. Sela
  • I. Ginsburg
  • T. Dishon
  • Z. Duchan
  • A. A. Garfunkel
Original Articles

Abstract

Blast transformation of human peripheral blood lymphocytes by PHA is shown to be modulated by lipoteichoic acid (LTA) ofStreptococcus mutans, by a cell-sensitizing factor ofActinomyces viscosus, as well as by a frozen and thawed extract of human leukocytes (LE). While small amounts of LE (5–50Μg/106 cells) significantly enhanced PHA-induced transformation, higher amounts showed a lesser effect on the blastogenic response. Both LTA and theA. viscosus extract did not cause any lymphocyte blastogenic effect when used alone. On the other hand LTA had an inhibitory effect and theA. viscosus extract had an enhancing effect when lymphocytes were pretreated by these agents and then exposed to PHA.

Keywords

Public Health Internal Medicine Blood Lymphocyte Peripheral Blood Lymphocyte Human Leukocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1982

Authors and Affiliations

  • M. N. Sela
    • 1
  • I. Ginsburg
    • 1
  • T. Dishon
    • 1
  • Z. Duchan
  • A. A. Garfunkel
    • 2
  1. 1.Department of Oral BiologyHebrew University-Hadassah School of Dental Medicine Founded by the Alpha Omega FraternityIsrael
  2. 2.Hospital Oral Medicine ServiceJerusalemIsrael

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