Mass spectrometry of steroid systems
- 18 Downloads
The mass spectra of cis- and trans-isomers in the series of estradiol, Δ4-3-ketosteroids, 14-hydroxy derivatives of estrone, and their D-homoanalogs were studied.
The mass spectra of cis-trans-isomers of polycyclic compounds well reflect the stereochemical peculiarities in the structure of their molecules, which makes it possible to assign the investigated compounds of this type to the trans- or cis-series on the basis of their mass spectra.
A configuration of the 8- and 14-centers in the molecules of methyl esters of Δ9(11)-dehydro-14β-hydroxy-8-isoestrone, Δ9(11)-dehydro-14α-hydroxy-D-homoestrone, and Δ9(11)-dehydro-14β-hydroxy-8-iso-D-homoestrone, as well as their 9,11-dihydro-derivatives, was proposed.
KeywordsMethyl Ester Mass Spectrometry Steroid Mass Spectrum
Unable to display preview. Download preview PDF.
- 1.V. I. Zaretskii, N. S. Vul'fson, V. L. Sadovskaya, S. N. Ananchenko, and I. V. Torgov, Dokl. AN SSSR,158, 385 (1964).Google Scholar
- 2.C. Djerassi, J. M. Wilson, H. Budzikiewicz, and J. W. Chamberlin, J. Amer. Chem. Soc.,84, 4544 (1962).Google Scholar
- 3.H. Budzikiewicz, C, Djerassi, and D. Williams, Interpretation of the Mass Spectra of Organic Compounds [Russian translation], “Mir” (1960), p. 174.Google Scholar
- 4.R. Shapiro and C. Djerassi, J. Amer. Chem. Soc.,86, 2825 (1964).Google Scholar
- 5.A. V. Zakharychev, I. Hora, S. N. Ananchenko, and I. V. Torgov, Tetrahedron Letters,1966, 3585.Google Scholar
- 6.J. Karliner, H. Budzikiewicz, and C. Djerassi, J. Organ. Chem.,31, 710 (1966).Google Scholar
- 7.R. Tschesche, P. Welsel, and H.-W. Vehlhaber, Tetrahedron21, 1797 (1965).Google Scholar