Calculating the influence of substituents upon the dissociation constants of carboxylic acids

  • A. N. Vereshchagin
  • S. G. Vul'fson
Physical Chemistry


  1. 1.

    A general formula was proposed for calculating the dissociation constants of substituted acids, considering all the electrostatic interactions in dissociated and nondissociated forms of substituted and unsubstituted acids.

  2. 2.

    Interactions of the charge- induced dipole type play an important role in a number of cases, in particular, determining the ortho- effect to one degree or another.

  3. 3.

    The values of ΔpK were calculated for ortho-toluic and propionic acids in accord with the experimental data.



Experimental Data Carboxylic Acid Electrostatic Interaction General Formula Dissociation Constant 
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Copyright information

© Consultants Bureau 1968

Authors and Affiliations

  • A. N. Vereshchagin
    • 1
    • 2
  • S. G. Vul'fson
    • 1
    • 2
  1. 1.A. E. Arbuzov Institute of Organic and Physical ChemistryAcademy of Sciences of the USSRUSSR
  2. 2.V. I. Ul'yanov-Lenin Kazan' State UniversityUSSR

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