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Heterocyclic analogs of corticosteroids

1. Syntheses based on octahydro-1,2-dimethyl-4(1H)-quinolone

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Summary

  1. 1.

    A study was made of some reactions for the introduction of oxidized side chain for the case of the two epimeric 4-ethynyldecahydro-1,2-dimethyl-4-quinolinols, which were prepared by the condensation of octahydro-1,2-dimethyl-4(lH)-quinolone with acetylene in liquid ammonia.

  2. 2.

    Two isomeric 4-acetyldecahydro-1,2-dimethyl-4-quinolinols, 4-(bromoacetyl)decahydro-1,2-dimethyl-4-quinolinol, and two isomeric 4-(epoxyethyl)decahydro-1,2-dimethyl-4-quinolinols were synthesized.

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Literature cited

  1. I. N. Nazarov and A. A. Akhrem, Zh. obshch. khimii26, 1186 (1956).

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Authors and Affiliations

  1. Institute of Physical Organic Chemistry, Academy of Sciences, Byelorussian SSR

    A. A. Akhrem, L. I. Ukhova & N. F. Uskoya

  2. N. D. Zelinskii Institute of Organic Chemistry, Academy of Sciences of the USSR, USSR

    A. A. Akhrem, L. I. Ukhova & N. F. Uskoya

Authors
  1. A. A. Akhrem
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  2. L. I. Ukhova
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  3. N. F. Uskoya
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Akhrem, A.A., Ukhova, L.I. & Uskoya, N.F. Heterocyclic analogs of corticosteroids. Russ Chem Bull 11, 281–285 (1962). https://doi.org/10.1007/BF00908035

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  • DOI: https://doi.org/10.1007/BF00908035

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