Summary
Ethanolamine was added to β, β-ditrifluoromethylacrylic ester and hexafluorovaline ester was hydroxyethylated. Both reactions yielded the ester of N-(β-hydroxyethyl)-hexafluorovaline, which could be used as the starting material for the synthesis of physiologically active substances.
Literature cited
H. Walborsky, M. Baum, D. Loncrini, J. Amer. Chem. Soc.77, 3637 (1955).
I. L. Knunyants and Yu. A. Cheburkov, Izvest. Akad. Nauk SSSR, Otdel. Khim. Nauk. (1960) (In the press).
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Knunyants, I.L., Cheburkov, Y.A. Some α-amino acids containing trifluoromethyl groups. Russ Chem Bull 9, 1411–1412 (1960). https://doi.org/10.1007/BF00907682
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DOI: https://doi.org/10.1007/BF00907682