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Synthese von (22R,25S)-16β-Amino-22,26-epiminocholestanen

Synthesis of (22R, 25S)-16β-amino-22,26-epimino-cholestanes

N-haltige Steroide, 1. Mitt.

  • Organische Chemie und Biochemie
  • Published:
Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

By reacting the known 16α-bromo-N-cyano-22,26-epimino-cholestanes (e.g.2) with NaN3 inDMF 16β-azido-N-cyano-22,26-epimino-cholestanes (e.g.4) were obtained. Reduction of4 with LiAlH4 gives 16β-amino-22,26-epimino-cholestane (9). Some acylated derivatives of9 are described, e.g. the known derivatives11 and13, which prove the stereochemistry at C-16.

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Literatur

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Authors and Affiliations

  1. Abteilung für Pharmazeutisch-chemische Forschung, Chemie Linz AG, St. Peter-Straße 25, A-4020, Linz, Österreich

    Rudolf Franzmair

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  1. Rudolf Franzmair
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Herrn Prof. Dr.K. Kratzl mit den besten Wünschen zum 60. Geburtstag von der Abteilung für Pharmazeutisch-chemische Forschung der Chemie Linz AG gewidmet.

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Franzmair, R. Synthese von (22R,25S)-16β-Amino-22,26-epiminocholestanen. Monatshefte für Chemie 107, 501–510 (1976). https://doi.org/10.1007/BF00906880

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  • DOI: https://doi.org/10.1007/BF00906880

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