Summary
We have worked out a preparative method for the synthesis of ω-thienylalkane acids by acylation of thiophene with ω-chloroalkane acid chlorides followed by conversion of the resulting ω-chloroalkyl(2-thienyl)ketones into the corresponding acids by reaction with sodium malonic ester or potassium cyanide, and reduction of the resulting products with their simultaneous hydrolysis.
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Literature cited
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Additional information
Here and later we mean ω-(2-thienyl)alkne acids.
We take this opportunity to thank R. Kh. Freidlina, A. A. Beér, and M. A. Besprozvannii for giving us enough ω-chloroalkane acids.
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Belen'kii, L.I., Tails, S.Z. & Gol'dfarb, Y.L. The synthesis of ω-thienylalkane acids from ω-chloroalkane acids. Russ Chem Bull 10, 1589–1591 (1961). https://doi.org/10.1007/BF00906162
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DOI: https://doi.org/10.1007/BF00906162