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Arrangement of hydrophobic portions on the active surface of cholinesterase

  • Physical Chemistry
  • Published:
Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The rate constants of the interaction of O-n-alkyl-S-(β-ethylmercaptoethyl) methylthiophosphonates and their methylsulfomethylates with cholinesterase were determined.

  2. 2.

    The anticholinesterase activity of the investigated compound depends greatly upon the length of the alkoxyl group.

  3. 3.

    Evidently there are several hydrophobic portions on the active surface of cholinesterase, situated both close to the esterase center and close to the anionic center.

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    A. A. Abdubakhabov, N. N. Godovikov, M. I. Kabachnik, S. S. Mikhailov, V. I. Rozengart & R. V. Sitkevich

  2. I. P. Pavlov First Leningrad Medical Institute, USSR

    A. A. Abdubakhabov, N. N. Godovikov, M. I. Kabachnik, S. S. Mikhailov, V. I. Rozengart & R. V. Sitkevich

Authors
  1. A. A. Abdubakhabov
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  2. N. N. Godovikov
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  3. M. I. Kabachnik
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  4. S. S. Mikhailov
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  5. V. I. Rozengart
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  6. R. V. Sitkevich
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 4, pp. 744–750, April, 1968.

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Abdubakhabov, A.A., Godovikov, N.N., Kabachnik, M.I. et al. Arrangement of hydrophobic portions on the active surface of cholinesterase. Russ Chem Bull 17, 719–723 (1968). https://doi.org/10.1007/BF00905739

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  • DOI: https://doi.org/10.1007/BF00905739

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