Conclusions
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1.
The possibility of a quantitative mass spectrometric determination of prednisolone and hydrocortisone present in a mixture was demonstrated.
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2.
The use of the MI-1305 mass spectrometer permits the analysis of a mixture of two steroid preparations within 30 min, with an amount of sample required of 0.01 μmole.
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Literature cited
A.A Akhrem and Yu.A. Titov, Microbiological Transformations of Steroids [in Russian], Nauka (1965).
G.K. Skryabin and L.M. Kogan, Izv. AN SSSR, Ser. Biol., No. 5, 742 (1967).
I.M Hais and K. Macek, Paper Chromatography [Russian translation], IL (1962).
J. Beinon, Mass Spectrometry and Its Use in Organic Chemistry [Russian translation], Mir (1964), p. 439.
A. M. Zyakun, “A thermostatically controlled system of evaporating the sample for the MKh-1303 mass spectrometer,” Pribory i Tekhnika Éksperimenta, No. 4, 162 (1967).
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 2, pp. 249–253, February, 1969.
The authors would like to express their gratitude to G.K. Skryabin for his valuable advice and aid during the performance of this work.
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Zyakun, A.M., Sterkin, V.É., Morozova, G.R. et al. Mass spectrometric investigations of organic compounds. Russ Chem Bull 18, 210–213 (1969). https://doi.org/10.1007/BF00905520
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DOI: https://doi.org/10.1007/BF00905520