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Inhibition of acetylcholinesterase with O-ethyl-S-(β-aryloxyethyl) methylthiophosphonates

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    The inhibition rate constants of acetylcholinesterase (AChE) by O-ethyl-S-(β-aryloxyethyl)methylthiophosphonates are determined.

  2. 2.

    The differences in the inhibiting ability of these compounds as regards AChE are determined mainly by the polar effects of the substituent in the benzene ring.

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Literature cited

  1. A. P. Brestkin, I. L. Brik, N. N. Godovikov, M. I. Kabachnik, and N. E. Teplov, Izv. AN SSSR, Ser. Khim., 1932 (1967).

  2. V. Ya. Yakovlev and R. I. Volkova, DAN SSSR,122, 843 (1959).

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  3. I. L. Brik and V. A. Yakovlev, Biokhimiya,27, 481 (1962).

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  4. M. Brenner, A. Nidervizer, G. Pataki, and R. Veder, Chromatography on Thin Layers [Russian translation], “Mir,” (1965), Chap 8, p. 104.

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    A. P. Brestkin, I. L. Brik, L. I. Ginetsinskaya, N. N. Godovikov, M. I. Kabachnik & N. E. Teplov

Authors
  1. A. P. Brestkin
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  2. I. L. Brik
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  3. L. I. Ginetsinskaya
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  4. N. N. Godovikov
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  5. M. I. Kabachnik
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  6. N. E. Teplov
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 9, pp. 2122–2123, September, 1968.

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Brestkin, A.P., Brik, I.L., Ginetsinskaya, L.I. et al. Inhibition of acetylcholinesterase with O-ethyl-S-(β-aryloxyethyl) methylthiophosphonates. Russ Chem Bull 17, 2011–2012 (1968). https://doi.org/10.1007/BF00905005

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  • DOI: https://doi.org/10.1007/BF00905005

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