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Zur Reaktion von Hydroxy- und Amino-pyridinen mit reaktiven Malonestern

Syntheses of heterocycles, CLX: the reaction of hydroxy and amino pyridines with reactive malonic esters

Synthesen von Heterocyclen, 160. Mitt.

  • Organische Chemie und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

The reaction of hydroxy and amino pyridines with 2.4.6-trichlorophenyl malonates (1) is discussed. Especially the reaction of 3-hydroxy-pyridine (4) with1 to 4-hydroxy-2H-pyrano[3.2-b]pyridine-2-ones (5 a-e), and the reaction of 2-amino-3-hydroxy-pyridine (15) to 2.9-dihydroxy-4H-pyrido-[1.2-a]pyrimidin-4-ones (16 d-f) is described.

Zusammenfassung

Das Verhalten der Hydroxy- und Amino-pyridine gegenüber Malonsäure-bis-2,4,6-trichlorphenylestern (1) wird untersucht. Im besonderen werden die Reaktionen des 3-Hydroxy-pyridins (4) mit1 zu 4-Hydroxy-2H-pyrano[3,2-b]pyridin-2-onen (5 a-e) und die des 2-Amino-3-hydroxy-pyridins (15) zu 2,9-Dihydroxy-4H-pyrido[1,2-a]pyrimidin-4-onen (16 d-f) beschrieben.

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Author information

Authors and Affiliations

  1. Institut für Organische Chemie der Universität Graz, Graz, Österreich

    Th. Kappe, M. A. A. Chirazi & E. Ziegler

Authors
  1. Th. Kappe
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  2. M. A. A. Chirazi
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  3. E. Ziegler
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Additional information

Herrn Prof. Dr. Dr. h. c.O. Kratky, Vorstand des Institutes für Physikal. Chemie der Universität Graz, zum 70. Geburtstag gewidmet.

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Kappe, T., Chirazi, M.A.A. & Ziegler, E. Zur Reaktion von Hydroxy- und Amino-pyridinen mit reaktiven Malonestern. Monatshefte für Chemie 103, 426–434 (1972). https://doi.org/10.1007/BF00904944

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  • DOI: https://doi.org/10.1007/BF00904944

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