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Anticholinesterase properties of O-ethyl S-(ω-phenylalkyl)methylthiophosphonates

  • A. P. Brestkin
  • N. N. Godovikov
  • E. I. Godyna
  • M. I. Kabachnik
  • E. V. Rozengart
Organic and Biological Chemistry
  • 14 Downloads

Conclusions

  1. 1.

    A series of O-ethyl S-(ω-phenylalkyl)methylthiophosphates was synthesized.

     
  2. 2.

    The anticholinesterase activity of the synthesized compounds depends strongly on the distance of the phenyl group in the alkyl thio substituent from the phosphorus atom.

     

Keywords

Phosphorus Phenyl Thio Phenyl Group Phosphorus Atom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Literature cited

  1. 1.
    A. P. Brestkin, N. N. Godovikov, E. I. Godyna, M. I. Kabachnik, E. V. Rozengart, and R. A. Yakovlev, DAN SSSR,158, 880 (1964).Google Scholar
  2. 2.
    M. I. Kabachnik, T. A. Mastryukova, N. I. Kurochkin, N. P. Rodionova, and E. M. Popov, ZhOKh,26, 2228 (1957).Google Scholar
  3. 3.
    V. A. Yakovlef and R. I. Volkova, DAN SSSR,128, 843 (1959).Google Scholar
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    I. L. Brik and V. A. Yakovlev, Biokhimiya,27, 481 (1962).Google Scholar
  5. 5.
    E. V. Rozengart, E. I. Godyna, and N. N. Godovikov, Izv. AN SSSR, Ser. Khim., 1370 (1965).Google Scholar

Copyright information

© Consultants Bureau 1969

Authors and Affiliations

  • A. P. Brestkin
    • 1
    • 2
  • N. N. Godovikov
    • 1
    • 2
  • E. I. Godyna
    • 1
    • 2
  • M. I. Kabachnik
    • 1
    • 2
  • E. V. Rozengart
    • 1
    • 2
  1. 1.Institute of Heteroorganic CompoundsAcademy of Sciences of the USSRUSSR
  2. 2.I. M. Sechenov Institute of Evolutionary Physiology and BiochemistryAcademy of Sciences of the USSRUSSR

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