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Isoelektronische Derivate des Sila-Clofenetamins und des Sila-Mebrophenhydramins

Isoelectronic derivatives of sila-clofenetamine and sila-mebrophenhydramine

Sila-Pharmaka, 6. Mitt.

  • Organische Chemie und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

Isoelectronic derivatives (A andB) and a homolog (C) of the two sila-antihistamines sila-clofenetamine and sila-mebrophenhydramine were synthesized for the first time by the steps shown in scheme 1. They and their unknown precursors II–IV were characterized by their physical (Table 1) and chemical properties and their structures confirmed by1H-NMR and mass spectroscopy (Tables 2 and 3). The pharmacological effects ofA andB were investigated and compared with those of the corresponding O-isosteric sila-antihistamines (Chapter 5).

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Authors and Affiliations

  1. Institut für Anorganische Chemie, Technische Universität Braunschweig, Pockelsstraße 4, D-3300, Braunschweig, Bundesrepublik Deutschland

    Reinhold Tacke & Ulrich Wannagat

Authors
  1. Reinhold Tacke
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  2. Ulrich Wannagat
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Additional information

5. Mitt.:R. Tacke undU. Wannagat, Mh. Chem.107, 1265 (1976).

Mit Auszügen aus der DissertationR. Tacke, Techn. Univ. Braunschweig 1974.

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Tacke, R., Wannagat, U. Isoelektronische Derivate des Sila-Clofenetamins und des Sila-Mebrophenhydramins. Monatshefte für Chemie 107, 1271–1279 (1976). https://doi.org/10.1007/BF00903817

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  • DOI: https://doi.org/10.1007/BF00903817

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