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Mannichbasen des 1-(3,3-Dimethyl-2-exo-norbornyl)-ethanons und ein neues Akineton®-analogon

Syntheses in the isocamphane series, III. Mannich bases of 1-(3,3-dimethyl-2-exo-norbornyl)-ethanone and a new analogue of Akineton®

Synthesen in der Isocamphanreihe, 3. Mitt.

  • Organische Chemie und Biochemie
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Monatshefte für Chemie / Chemical Monthly Aims and scope Submit manuscript

Abstract

Syntheses of someMannich bases of the title compound (2) are described. The properties and the spectra of the new compounds3–12 are discussed. The aminomethylating group usually attacks at the side chain but in one case also a substitution at the bicyclus has taken place. Theexo-configuration at C-2 of the bicyclus of theMannich bases is retained. TheGrignard reaction of9 leads to an analogue of the known Akineton®, a drug againstParkinson disease.

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Authors and Affiliations

  1. Pharmazeutisch-Chemisches Institut, Universität Wien, Währinger Straße 10, A-1090, Wien, Österreich

    Gerhard Buchbauer

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  1. Gerhard Buchbauer
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Additional information

Nach: Deutscher Zentralausschuß für Chemie: Internationale Regeln für die chemische Nomenklatur und Terminologie, Verlag Chemie 1975, soll statt z. B. „äthyl”- „ethyl”- geschrieben werden.

2. Mitt.:G. W. Hana u. a., Mh. Chem.107, 945 (1976).

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Buchbauer, G. Mannichbasen des 1-(3,3-Dimethyl-2-exo-norbornyl)-ethanons und ein neues Akineton®-analogon. Monatshefte für Chemie 108, 21–28 (1977). https://doi.org/10.1007/BF00900903

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