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Applied physics

, Volume 8, Issue 4, pp 341–348 | Cite as

A high-sensitivity laser microprobe mass analyzer

  • F. Hillenkamp
  • E. Unsöld
  • R. Kaufmann
  • R. Nitsche
Contributed Papers

Abstract

A laser microprobe mass analyzer has been developed. It is intended for application in biomedical and physiological research. A frequency-doubled ruby laser is focussed through an incident light microscope to a spot of minimally 0.5 μm in diameter on a thin section specimen of 0.1–1.5 μm thickness. The microplasma generated from the irradiated volume is analyzed in a time-of-flight mass spectrometer recording the complete spectrum for each shot. From lithium doped epoxy resin (5 ppm by weight), used as an organic standard, 1.4×10−19g or 1.4×104 atoms of the6Li isotope have been detected. This sensitivity corresponds to that of ion microprobes but is at least an order of magnitude higher than obtained with electron probe X-ray microanalyzers.

Index Headings

Laser microprobe Micro-mass analysis 

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References

  1. 1.
    D.Glick: InModern Techniques in Physiological Sciences, ed. by J.F.Gross, R.Kaufmann, E.Wetterer (Academic Press, London and New York 1973), p. 217Google Scholar
  2. 2.
    H.Moenke, L.Moenke:Laser Micro-Spectrochemical Analysis (Adam Hilger Ltd., London 1973)Google Scholar
  3. 3.
    K.W.Marich: InMicroprobe Analysis as Applied to Cells and Tissues, ed. by T.A.Hall, P.Echlin, R.Kaufmann (Academic Press, London and New York 1974), p. 15Google Scholar
  4. 4.
    T.A.Hall: InMicroprobe Analysis as Applied to Cells and Tissues, ed. by T.A.Hall, P.Echlin, R.Kaufmann (Academic Press, London and New York 1974), p. XVGoogle Scholar
  5. 5.
    B.E.Knox: InDynamic Mass Spectrometry, Vol. II, ed. by D.Price, J.E.Williams (Heyden and Son Ltd. London 1971) p. 61Google Scholar
  6. 6.
    R.E.Honig: InLaser Interaction and Related Plasma Phenomena, ed. by H.J.Schwarz, H.Hora (Plenum Press, New York and London 1971) p. 85Google Scholar
  7. 7.
    B.E.Knox: InTrace Analysis by Mass Spectrometry, ed. by A.J.Ahcarn (Academic Press, London and New York, 1972) p. 423Google Scholar
  8. 8.
    F.J.Vastola, A.J.Pirone: InAdvances in Mass Spectrometry, Vol. IV, ed. by E.Kendrick (Applied Science Publishers, London 1968), p. 107Google Scholar
  9. 9.
    M.W.Berns: InLaser Applications in Medicine and Biology, Vol. II, ed. by M.L.Wolbarsht (Plenum Press, New York and London 1974), p. 1Google Scholar
  10. 10.
    N.C.Fenner, N.R.Daly: J. Mat. Sci.3, 259 (1968)CrossRefGoogle Scholar
  11. 11.
    M.K.Chun, K.Rose: J. Appl. Phys.41, 614 (1970)CrossRefADSGoogle Scholar
  12. 12.
    N.G.Basov, O.N.Krokhin, G.V.Sklizkov: Zh. Eksperim. Theor. Fiz.6, 683 (1967)Google Scholar
  13. 13.
    N.G.Basov, V.A.Boyko, V.A.Gribkov, S.M.Zakharov, O.N.Krokhin, G.V.Sklizkov: JETP34, 81 (1972)Google Scholar
  14. 14.
    S.I.Anisimov: JETP31, 181 (1970)Google Scholar
  15. 15.
    G.Herziger, R.Stemme, H.Weber: IEEE J. Quant. Electr.QE-10, 175 (1974)CrossRefGoogle Scholar
  16. 16.
    F.J.Vastola, A.J.Pirone, P.H.Given, R.R.Dutcher: InSpectrometry of Fuels, ed. by R.A.Friede (Plenum Press, New York 1970), p. 29Google Scholar
  17. 17.
    F.Hillenkamp, R.Kaufmann, E.Remy: InModern Techniques in Physiological Sciences, ed. by J.F.Gross, R.Kaufmann, E.Wetterer (Academic Press, London and New York 1973), p. 225Google Scholar
  18. 18.
    F.Hillenkamp, R.Kaufmann, R.Nitsche, E.Remy, E.Unsöld: InMicroprobe Analysis as Applied to Cells and Tissues, ed. by T.A.Hall, P.Echlin, R.Kaufmann (Academic Press, London and New York 1974), p. 1Google Scholar
  19. 19.
    E.Remy, F.Hillenkamp, R.Nitsche, E.Unsöld: Biomed. Technik20, Supplement, 287 (1975)Google Scholar
  20. 20.
    N.C.Fenner, N.R.Daly: Rev. Sci. Instr.37, 1068 (1966)CrossRefGoogle Scholar
  21. 21.
    E.Bernal, J.F.Ready: J. Appl. Phys.45, 2980 (1974)CrossRefADSGoogle Scholar
  22. 22.
    G.P.Megrue: Science157, 1555 (1967)CrossRefADSGoogle Scholar
  23. 23.
    A.R.Spurr: InMicroprobe Analysis as Applied to Cells and Tissues ed. by T.A.Hall, P.Echlin, R.Kaufmann (Academic Press, London and New York 1974), p. 213Google Scholar
  24. 24.
    R.Kaufmann, F.Hillenkamp, R.Nitsche, M.Schürmann, E. Unsöld: J. Microscop. Biol. Cell. (in press)Google Scholar
  25. 25.
    I.Harding-Barlow: InLaser Applications in Medicine and Biology, Vol. II, ed. by M.L.Wolbarsht (Plenum Press, New York and London 1974), p. 133Google Scholar
  26. 26.
    J.Eloy: Int. J. Mass Spectrom. Ion Phys.6, 101 (1971)CrossRefGoogle Scholar
  27. 27.
    F.J.Vastola, A.J.Pirone: Fuel Chem. Amer. Chem. Soc.10, C53 (1966)Google Scholar
  28. 28.
    W.K.Joy, B.G.Renben: InDynamic Mass Spectrometry, Vol. 1, ed. by D. Price, J.E.Williams (Heyden and Son Ltd. London 1970) p. 183Google Scholar
  29. 29.
    K.A.Lincoln: Pure Appl. Chem., Supplement: “High Temperature Technology”, 323 (1969)Google Scholar
  30. 30.
    K.A.Lincoln: Int. J. Mass Spectrom. Ion Phys.13, 45 (1974)CrossRefGoogle Scholar
  31. 31.
    H.E.Winters, E.Kay: J. Appl. Phys.43, 789 (1972)CrossRefADSGoogle Scholar
  32. 32.
    H.-J.Dietze, H.Zahn: Exp. Techn. Phys.20, 401 (1972)Google Scholar

Copyright information

© Springer-Verlag 1975

Authors and Affiliations

  • F. Hillenkamp
    • 1
  • E. Unsöld
    • 1
  • R. Kaufmann
    • 2
  • R. Nitsche
    • 2
  1. 1.Gesellschaft für Strahlen- und Umweltforschung mbH, MünchenNeuherbergGermany
  2. 2.Institut für klinische PhysiologieUniversität DüsseldorfDüsseldorlGermany

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