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A genetic and functional characterization of adenine mutants induced in yeast by 1-nitroso-imidazolidone-2 and nitrous acid

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Summary

The mutational activity of NIL and HNO2 is compared in a forward mutation system of Saccharomyces cerevisiae involving ad1 and ad2 loci. The comparison includes the distribution of ad1 to ad2 mutations as well as certain functional aspects, namely, the frequency of KCl remedials and intragenic complementation with the tester strains. The results show that NIL and HNO2 mutants are similar both in the distribution of ad1 to ad2 and in their functional aspects. Our findings suggest, furthermore, that in a certain group of mutants—mutants complementing with the tester strains—complementation is incompatible with KCl repair.

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  1. Forstbotanisches Institut der Universität Freiburg i. Br., Bertoldstr. 17, 78, Freiburg i. Br.

    N. Nashed & G. Jabbur

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  1. N. Nashed
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  2. G. Jabbur
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Nashed, N., Jabbur, G. A genetic and functional characterization of adenine mutants induced in yeast by 1-nitroso-imidazolidone-2 and nitrous acid. Zeitschrift für Vererbungslehre 98, 106–110 (1966). https://doi.org/10.1007/BF00897182

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