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Mehrfachinfektion mit RNS-Phagen

II. Mitteilung Interferenz bei fr

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Summary

Interference could be demonstrated to occur between fr- and f2-mutants, indicating that the observed effect of mutual exclusion between fr+ and fr-A 105 is of general nature. Phage lysates, inactivated during storage at 4o, showed strong interference with homologous phages. This phenomenon may serve as an explanation for the “temporary immunity” of fr-sensitive cells. UV-inactivated phages interfered with superinfecting viable phages if present at low input multiplicity. This interference showed a maximum of expression immediately upon mixing cells with inactivated phages. During the subsequent 15 min the amount of interference decreased and stayed constant from then on. Cells, pre-treated with UV-inactivated phages permitted the adsorption of challenge virus, not however its invasion.

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Authors and Affiliations

  1. School of Medicine, Department of Biochemistry, New York University, 550 First Avenue, 10016, New York, N.Y., USA

    P. Knolle

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  1. P. Knolle
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Die Arbeit wurde im ehemaligen Max-Planck-Institut für vergleichende Erbbiologie und Erbpathologie, Berlin-Dahlem, begonnen und mit einem Habilitationsstipendium der Deutschen Forschungsgemeinschaft beendet.

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Knolle, P. Mehrfachinfektion mit RNS-Phagen. Zeitschrift für Vererbungslehre 98, 270–277 (1966). https://doi.org/10.1007/BF00888952

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