Zeitschrift für Vererbungslehre

, Volume 89, Issue 1, pp 1–6 | Cite as

Interactions between ionizing radiation and chemical mutagens

  • Irwin I. Oster


  1. 1.

    X-rays in combination with urethane or mustard gas exhibit an additive effect as regards the formation of sex-linked recessive lethal mutations and chromosome breaks when applied toDrosophila melanogaster spermatozoa.

  2. 2.

    Their action in combination on the formation of translocations is synergistic.

  3. 3.

    The ends of chromosomes broken by X-rays, mustard gas, and urethane are as capable of rejoining with those produced by the same agent as the X-ray produced-ones are of rejoining with those produced by either mustard gas or urethane to form chromosomal disarrangements.



Radiation Urethane Chromosome Break Chemical Mutagen Lethal Mutation 
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Literature cited

  1. Auerbach, C.: Chemical induction of mutations I. Discovery of the mutagenic action of mustard gas. Proc. Internat. Congr. Genet. 8th Congr., Stockholm, 1949. Hereditas (Lund) Suppl.1949, 128.Google Scholar
  2. Auerbach, C., andH. Moser: The effect of oxygen concentration on the mutagenic action of mustard gas. Experientia (Basel)7, 341 (1951).Google Scholar
  3. Auerbach, C., andJ. M. Robson: Chemical production of mutations. Nature (Lond.)157, 302 (1946).Google Scholar
  4. ——: The production of mutations by chemical substances. Proc. Roy. Soc. Edinburgh, Sect. B62, 271 (1947).Google Scholar
  5. Carlson, J. G.: Immediate effects on division, morphology, and viability of the cell. In: Radiation Biology, Part I, p. 763. A. Hollaender, edit. 1954.Google Scholar
  6. Karnofsky, D. A., J. H. Burcheval, R. A. Ormsbec, I. Cornman andC. P. Rhoads: Experimental observations on the effects of the nitrogen mustards on neoplastic tissues. Cancer Res.7, 50 (1947).Google Scholar
  7. Kirschbaum, A., andS. Kawamoto: Potentiating effect of urethane on the induction of mouse leukemia by X-rays. Proc. Amer. Assoc. Cancer Res.2, 222 (1957).Google Scholar
  8. Lindsley, D. L., andE. Novitski: The synthesis of an attached XY chromosome. Dros. Inf. Serv.24, 84 (1950).Google Scholar
  9. Muller, H. J.: Artificial transmutation of the gene. Science (Lancaster, Pa.)66, 84 (1927).Google Scholar
  10. —: Multipurpose stocks for studies of mutagenesis. Dros. Inf. Serv.28, 144 (1954).Google Scholar
  11. Nasrat, G. E., W. D. Kaplan andC. Auerbach: A quantitative study of mustard gas induced chromosome breaks and rearrangements inDrosophila melanogaster. Z. Vererbungslehre86, 249 (1954).Google Scholar
  12. Oehlkers, F.: Die Auslosung von Chromosomenmutationen in der Meiosis durch Einwirkung von Chemikalien. Z. Vererbungslehre81, 313 (1943).Google Scholar
  13. Oster, I. I.: The effect of mitotic poisons on the sensitivity ofDrosophila germ cells to ionizing radiation. Congr. No. (8Th Internat. Congr. for Cell Biology.) Excerpta med.8, 406 (1954).Google Scholar
  14. —: The induction of mutations inDrosophila melanogaster by orally administered ethyl carbamate (urethane). Rec. Genet. Soc.24 and Genetics40, 588 (1955).Google Scholar
  15. Paterson, E., andM. V. Thompson: Effect of urethane combined with X rays on chick fibroblasts. Nature (Lond.)163, 563 (1949).Google Scholar
  16. Sparrow, A. H.: Radiation sensitivity of cells during mitotic and meiotic cycles with emphasis on possible cytochemical changes. Ann. New York Acad. Sci.51, 1508 (1951).Google Scholar
  17. Stadler, L. J.: On the genetic nature of induced mutations in plants. Proc. 6th Internat. Congr. Genet.1, 274 (1932).Google Scholar
  18. Swanson, C. P.: The effect of supplementary factors on the radiation-induced frequency of mutations inAspergillus terreus. J. Cellular Comp. Physiol. Suppl.1, 39, 27 (1952).Google Scholar

Copyright information

© Springer-Verlag 1958

Authors and Affiliations

  • Irwin I. Oster
    • 1
  1. 1.Department of ZoologyIndiana UniversityBloomington

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