Abstract
We describe the case of a 40-year-old male patient who had presented clinically as primary lateral sclerosis for the past 10 years and neuropathologically as diffuse Lewy body disease (DLBD). Neuropathology demonstrated DLBD as an almost ubiquitous disorder of the neuronal cytoskeleton.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bancher C, Lassmann H, Budka H, Jellinger K, Grundke-Igbal I, Igbal K, Wiche G, Scitelberger F, Wisniewski HM (1989) An antigenic profile of Lewy bodies: immunocytochemical indication for protein phosphorylation and ubiquitination. J Neuropathol Exp Neurol 48:81–93
Burkhardt CR, Filley CM, Kleinschmidt-DeMasters BK, Monte S de la, Norenberg MD, Schneck SA (1988) Diffuse Lewy body disease and progressive dementia. Neurology 38:1520–1528
Crystal HA, Dickson DW, Lizardi JE, Davies P, Wolfson LI (1990) Antemortem diagnosis of diffuse Lewy body disease. Neurology 40:1523–1528
Dale GE, Probst A, Luthert P, Martin J, Anderton BH, Leigh PN (1992) Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol (Berl) 83:525–529
Delisle MB, Gorce P, Hirsch E, Hauw JJ, Rascol A, Bouissou H (1987) Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions. Acta Neuropathol (Berl) 75:104–108
Gibb WRG, Esiri MM, Lees AJ (1985) Clinical and pathological features of diffuse cortical Lewy body disease (Lewy body dementia). Brain 110:1131–1153
Kato T, Katagiri T, Hirano A, Sasaki H, Arai S (1988) Sporadic lower motor neuron disease with Lewy body-like inclusions: a new subgroup? Acta Neuropathol (Berl) 76:208–211
Kosaka K (1990) Diffuse Lewy body disease in Japan. J Neurol 237:197–204
Kosaka K, Yoshimura M, Ikeda K, Budka H (1984) Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of various degree — a new disease? Clin Neuropathol 3:185–192
Lennox G, Lowe J, Landon M, Byrne EJ, Mayer RJ, Godwin-Austen RB (1989) Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry. J Neurol Neurosurg Psychiatry 52:1236–1247
Lewy FH (1912) Paralysis agitans. I. Pathologische Anatomie. In: Lewandowsky M (ed) Handbuch der Neurologie. Springer, Berlin, pp 920–933
Masliah E, Galasko D, Wiley CA, Hansen LA (1989) Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia. Acta Neuropathol (Berl) 80:453–458
Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC (1992) Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 115:495–520
Sugiyama H, Hainfellner JA, Yoshimura M, Budka H (1994) Neocortical changes in Parkinson's disease, revisited. Clin Neuropathol 13:55–59
Yoshimura M (1983) Cortical changes in the parkinsonian brain: a contribution to the delineation of “diffuse Lewy body disease”. J Neurol 229:17–32
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hainfellner, J.A., Pilz, P., Lassmann, H. et al. Diffuse Lewy body disease as substrate of primary lateral sclerosis. J Neurol 242, 59–63 (1995). https://doi.org/10.1007/BF00887816
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00887816