Journal of Neurology

, Volume 242, Issue 5, pp 332–334 | Cite as

Sequence of the human homologue of a mitochondrially encoded murine transplantation antigen in patients with multiple sclerosis

  • R. M. Chalmers
  • A. E. Harding
  • N. Robertson
  • H. Kellar-Wood
  • D. A. S. Compston
Original Communication


There is some evidence that mitochondrial genes may contribute to susceptibility to multiple sclerosis (MS), and a mitochondrial DNA-encoded peptide, the N-terminal portion of NADH-dehydrogenase subunit 1, acts as a transplantation antigen in mice. We have analysed the DNA sequence of the corresponding region of human mitochondria) DNA in 87 patients with MS, 10 with Leber's hereditary optic neuropathy in association with an MS like illness, and 31 control subjects. This sequence appears to be highly conserved. Only three base pair changes were identified, each being found once only in one control and two patients, and these are likely to be harmless polymorphisms. There is thus no evidence that polymorphism in this region contributes to genetic susceptibility in MS.

Key words

Multiple sclerosis Mitochondrial DNA 


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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. M. Chalmers
    • 1
  • A. E. Harding
    • 1
  • N. Robertson
    • 2
  • H. Kellar-Wood
    • 2
  • D. A. S. Compston
    • 2
  1. 1.Institute of NeurologyUniversity Department of Clinical Neurology (Neurogenetics Section)LondonUK
  2. 2.Addenbrooke's HospitalUniversity of Cambridge Neurology UnitCambridgeUK

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