Pediatric Nephrology

, Volume 6, Issue 3, pp 231–235 | Cite as

Crescentic glomerulonephritis in children

  • Helena M. P. F. Jardim
  • Janet Leake
  • R. Anthony Risdon
  • T. Martin Barratt
  • Michael J. Dillon
Original Article


Data on patients with crescentic glomerulonephritis (>50% glomeruli with crescents), referred to the Hospital for Sick Children during the past 13 years, were reviewed. Thirty patients (13 male, 17 female) aged 3.7–15.7 years (mean 9.5) were evaluated. Initial clinical features included: oedema (24/30), hypertension (19/30), gross haematuria (15/30), oliguria (15/30) and a decreased glomerular filtration rate (GFR<30 ml/min per 1.73 m2) (22/30). Henoch-Schönlein purpura was present in 9 patients, microscopic polyarteritis in 3, polyarteritis nodosa in 1, Wegener's granulomatosis in 1, systemic lupus erythematosus in 1, post-streptococcal glomerulonephritis in 2, mesangiocapillary glomerulonephritis in 7, anti-glomerular basement membrane glomerulonephritis in 2, and 4 were idiopathic. In 10 patients 50%–79% of glomeruli were affected by crescentic changes (group 1) and in the remaining 20, 80% or more (group 2). The crescents were cellular, fibrocellular or fibrous, and the degree of sclerosis was assessed. Patients in both groups were treated with plasma exchange, corticosteroids, anticoagulants, cyclophosphamide and azathioprine in different combinations. On follow-up, 3 patients were dead, 1 was lost to follow-up, 12 were on dialysis/transplant programmes, 4 had a GFR of less than 30 and 10 a GFR of more than 30 ml/min per 1.73 m2. In our experience, 50% progressed to end-stage renal failure. The interval between disease onset and start of treatment was a prognostic factor for outcome. Fibrous crescents were associated with a worse outcome than fibrocellular crescents (P<0.05). Outcome was not, however, related to the percentage of glomeruli affected (P>0.05). Although the effectiveness of the individual components of the treatment regimens used was difficult to assess, one-third of patients at the latest follow-up had a GFR of more than 30 ml/min per 1.73 m2.

Key words

Crescentic glomerulonephritis Rapidly progressive glomerulonephritis 


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Copyright information

© IPNA 1992

Authors and Affiliations

  • Helena M. P. F. Jardim
    • 1
  • Janet Leake
    • 2
  • R. Anthony Risdon
    • 2
  • T. Martin Barratt
    • 1
  • Michael J. Dillon
    • 1
  1. 1.Renal UnitHospital for Sick ChildrenLondonUK
  2. 2.Department of HistopathologyHospital for Sick ChildrenLondonUK

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