Prognosis of patients with unilateral renal agenesis


The clinical course was reviewed in 157 patients with unilateral renal agenesis and a normal contralateral kidney for the purpose of establishing a prognosis. There were 85 males (54%) and 72 females (46%). The mean age at diagnosis of unilateral renal agenesis was 37 years. The mean years at risk was 56. Proteinuria (>150 mg/24h) was found in 19% of the 37 patients tested (P<0.001), hypertension developed in 47% of the 47 patients tested (P=0.010), and renal function (adjusted for age and sex) was decreased in 13% of the 32 patients tested (P=0.001). An increased filtration fraction was found in 7 (54%) of 13 patients evaluated. At the completion of this study, 114 patients (73%) were alive, and the survival rate was similar to that of age-, sex-matched United States life tables. Forty-three patients (27%) died; 6 deaths (4%) were caused by renal failure. Our review indicates that patients with unilateral renal agenesis and a normal solitary kidney are at increased risk of proteinuria, hypertension, and renal insufficiency. Therefore, it is essential to have prolonged and careful follow-up and to employ strategies that maximize renal preservation.

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Correspondence to Stephen A. Kramer.

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Argueso, L.R., Ritchey, M.L., Boyle, E.T. et al. Prognosis of patients with unilateral renal agenesis. Pediatr Nephrol 6, 412–416 (1992).

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Key words

  • Hyperfiltration
  • Hypertension
  • Proteinuria
  • Renal insufficiency
  • Unilateral renal agenesis