Pediatric Nephrology

, Volume 6, Issue 5, pp 412–416 | Cite as

Prognosis of patients with unilateral renal agenesis

  • Luis R. Argueso
  • Michael L. Ritchey
  • Emmett T. BoyleJr.
  • Dawn S. Milliner
  • Erik J. Bergstralh
  • Stephen A. Kramer
Original Article


The clinical course was reviewed in 157 patients with unilateral renal agenesis and a normal contralateral kidney for the purpose of establishing a prognosis. There were 85 males (54%) and 72 females (46%). The mean age at diagnosis of unilateral renal agenesis was 37 years. The mean years at risk was 56. Proteinuria (>150 mg/24h) was found in 19% of the 37 patients tested (P<0.001), hypertension developed in 47% of the 47 patients tested (P=0.010), and renal function (adjusted for age and sex) was decreased in 13% of the 32 patients tested (P=0.001). An increased filtration fraction was found in 7 (54%) of 13 patients evaluated. At the completion of this study, 114 patients (73%) were alive, and the survival rate was similar to that of age-, sex-matched United States life tables. Forty-three patients (27%) died; 6 deaths (4%) were caused by renal failure. Our review indicates that patients with unilateral renal agenesis and a normal solitary kidney are at increased risk of proteinuria, hypertension, and renal insufficiency. Therefore, it is essential to have prolonged and careful follow-up and to employ strategies that maximize renal preservation.

Key words

Hyperfiltration Hypertension Proteinuria Renal insufficiency Unilateral renal agenesis 


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Copyright information

© IPNA 1992

Authors and Affiliations

  • Luis R. Argueso
    • 1
  • Michael L. Ritchey
    • 1
  • Emmett T. BoyleJr.
    • 5
  • Dawn S. Milliner
    • 2
  • Erik J. Bergstralh
    • 3
    • 4
  • Stephen A. Kramer
    • 1
  1. 1.Department of UrologyMayo ClinicRochesterUSA
  2. 2.Division of Nephrology and Internal Medicine and Section of General Pediatrics and Pediatric NephrologyMayo ClinicRochesterUSA
  3. 3.Section of BiostatisticsMayo ClinicRochesterUSA
  4. 4.Mayo FoundationRochesterUSA
  5. 5.Section of UrologyMayo Clinic ScottsdaleScottsdaleUSA

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