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Investigational New Drugs

, Volume 11, Issue 1, pp 85–86 | Cite as

Phase II trial of gallium nitrate in previously treated patients with small cell lung cancer

  • Jose Baselga
  • Mark G. Kris
  • Howard I. Scher
  • Mary Phillips
  • Robert T. Heelan
Article

Abstract

Gallium nitrate is a group IIIa metal that was found to be active in animal species [1]. Gallium nitrate exerts its antitumor effects via a transferrin binding mechanism [2]. This agent is of interest in small cell lung cancer since 26 of 27 small cell carcinoma cell lines tested had increased levels of transferrin receptors [3]. In a phase I study using a continuous infusion, the dose limiting toxicity was nausea when gallium nitrate was given at doses of 400 mg/m2/day. Other effects included elevations of serum creatinine, hypocalcemia, hypomagnesemia, decreased hearing and paresthesias [4]. Activity has been seen in pretreated patients with malignant lymphoma, bladder carcinoma and small numbers of patients with small cell lung carcinoma [4, 5]. To determine the activity of continuous infusion gallium nitrate, this phase II trial was undertaken in patients with small cell lung cancer previously treated with chemotherapy.

Key words

gallium nitrate small cell lung cancer phase II trial 

References

  1. 1.
    Hart N, Smith C, Vancey S, et al.: Toxicity and antitumor activity of gallium nitrate and periodically related metal salts. J Natl Cancer Inst 47:1121–7, 1971PubMedGoogle Scholar
  2. 2.
    Chitamber C, Massey E, Seligman P: Regulation of transferrin receptor expression on human leukemic cells during proliferation and induction of differentiation. Effects of gallium and dimethylsulfoxide. J Clin Invest 72:1314–25, 1983PubMedGoogle Scholar
  3. 3.
    Carney D. IASLC Workshop on Small Cell Lung Cancer, Gleneagles, Scotland. 1984Google Scholar
  4. 4.
    Warrell R, Coonley C, Straus D, et al.: Treatment of patients with advanced malignant lymphomas using gallium nitrate administered as a seven day continuous infusion. Cancer 51:1982–7, 1983PubMedGoogle Scholar
  5. 5.
    National Cancer Institute, Investigator's Update: Gallium Nitrate, 1983Google Scholar

Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Jose Baselga
    • 1
  • Mark G. Kris
    • 1
  • Howard I. Scher
    • 1
  • Mary Phillips
    • 1
  • Robert T. Heelan
    • 1
  1. 1.Thoracic Oncology Service, Division of Solid Tumor Oncology, Department of Medicine and Department of Medical ImagingMemorial Sloan-Kettering Cancer and Cornell University Medical CollegeNew YorkUSA

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