Journal of Neurology

, Volume 241, Issue 9, pp 567–569 | Cite as

Valproate encephalopathy and hypocarnitinaemia in diabetic patients

  • Lea Averbuch-Heller
  • Tamir Ben-Hur
  • Avinoam Reches
Original Communication


Two patients with epilepsy and diabetes mellitus developed encephalopathy while on valproate monotherapy. Low plasma carnitine levels were found. Discontinuation of valproate was followed by clinical recovery and normalization of carnitine levels. Both valproate treatment and diabetes mellitus may contribute to secondary carnitine deficiency, with resultant encephalopathy. Thus, diabetic patients may be at increased risk of developing valproate encephalopathy associated with hypocarnitinaemia.

Key words

Valproate Diabetes Hypocarnitinaemia Encephalopathy 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Lea Averbuch-Heller
    • 1
  • Tamir Ben-Hur
    • 1
  • Avinoam Reches
    • 1
  1. 1.Department of NeurologyHadassah University Hospital and Hebrew University, Hadassah Medical SchoolJerusalemIsrael

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