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Central alveolar hypoventilation associated with paraneoplastic brain-stem encephalitis and anti-Hu antibodies

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Abstract

We describe a patient with a paraneoplastic brain-stem encephalitis due to an occult small cell carcinoma of the lung. He developed episodes of central sleep apnoea culminating in acute respiratory failure. Antibodies resembling anti-Hu antibodies were demonstrated in both serum and cerebrospinal fluid.

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References

  1. Anderson NE, Rosenblum MK, Gratis F, Wiley RG, Posner JB (1988) Autoantibodies in paraneoplastic syndromes with small cell lung cancer. Neurology 38:1391–1398

    Google Scholar 

  2. Baker AB, Matzke HA, Brown JR (1950) Poliomyelitis: bulbar poliomyelitis. A study of medullary function. Arch Neural Psychiatry 63:257–281

    Google Scholar 

  3. Belmusto L, Brown E, Owens G (1963) Clinical observations on respiratory and vasomotor disturbances as related to cervical cordotomies. J Neurosurg 20:225–232

    Google Scholar 

  4. Case records of the Massachusetts General Hospital Case 39 — 1988 (1988) N Engl J Med 319:849–860

    Google Scholar 

  5. Cohn JE, Kuida H (1962) Primary alveolar hypoventilation associated with western equine encephalitis. Ann Intern Med 56:633–644

    Google Scholar 

  6. Cumminskey J, Guilleminault C, Davis R, Dunca K, Golden J (1987) Automatic respiratory failure: sleep studies and Leigh's Disease. Neurology 37:1876–1878

    Google Scholar 

  7. Devereaux MW, Keane JR, Davis RL (1973) Automatic respiratory failure associated with infarction of the medulla. Arch Neurol 29:46–52

    Google Scholar 

  8. Furneaux HM, Reich L, Posner JB (1990) Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology 40:1085–1091

    Google Scholar 

  9. Gomm SA, Thatcher N, Barber PV, Cumming WJK (1990) A clinicopathological study of the paraneoplastic neuromuscular syndromes associated with lung cancer. Q J Med 278:577–595

    Google Scholar 

  10. Graus F, Elkon KB, Cordon-Cardo C, Posner JB (1986) Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumour. Am J Med 80:45–52

    Google Scholar 

  11. Greenlee JE, Sun M (1985) Immunofluorescent labelling of non human cerebellar tissue with sera from patients with systemic cancer and paraneoplastic cerebellar degeneration. Acta Neuropathol (Berl) 67:226–229

    Google Scholar 

  12. Henson RA, Urich H (1982) Cancer and the nervous system: the neurological manifestations of systemic disease. Blackwell, Oxford

    Google Scholar 

  13. Howard RS, Newsom Davis J (1992) The neural control of respiratory function. In: Crockard HA, Hayward R, Hoff JT (ed) Neurosurgery: the scientific basis of clinical practice, 2nd edn. Blackwell, Oxford, pp 318–333

    Google Scholar 

  14. Howard RS, Wiles CM, Hirsch NP, Loh L, Spencer GT, Newsom Davis J (1992) Respiratory involvement in multiple sclerosis. Brain 115:474–494

    Google Scholar 

  15. Hughes JMB (1967) Central respiratory failure reversed by treatment. Brain 90:675–680

    Google Scholar 

  16. Jensen TH, Hansen PB, Brodersen P (1988) Ondine's curse inListeria monocytogenes brain stem encephalitis. Acta Neurol Scand 77:505–506

    Google Scholar 

  17. Kaplan AM, Itabashi HH (1974) Encephalitis associated with carcinoma. J Neurol Neurosurg Psychiatry 37:1166–1175

    Google Scholar 

  18. Kim R (1968) The chronic residual respiratory disorder in post-encephalitic Parkinsonism. J Neurol Neurosurg Psychiatry 31:393–398

    Google Scholar 

  19. Lange LS, Laszlo G (1965) Central tumour presenting with hyperventilation. J Neurol Neurosurg Psychiatry 28:317–319

    Google Scholar 

  20. Lockwood AH (1976) Shy-Drager syndrome with abnormal respiration and ADH release. Arch Neurol 33:292–295

    Google Scholar 

  21. Mellins RB, Balfour HH Jr, Turino GM, Winters RW (1970) Failure of automatic control of ventilation (Ondine's curse). Report of an infant born with this syndrome and review of the literature. Medicine (Baltimore) 49:487–504

    Google Scholar 

  22. Nathan PW (1963) The descending respiratory pathways in man. J Neurol Neurosurg Psychiatry 26:487–499

    Google Scholar 

  23. Nelson DA, Ray CD (1968) Respiratory arrest from seizure discharges in limbic system. Arch Neurol 19:199–207

    Google Scholar 

  24. O'Neil JH, Murray NMF, Newsom Davis J (1988) The Lambert-Eaton myasthenic syndrome. Brain 111:577–596

    Google Scholar 

  25. Pauzner R, Mouallem M, Sadeh M, Tadmor R & Farfel Z (1989) High incidence of primary cerebral lymphoma in tumour- induced central neurogenic hyperventilation. Arch Neurol 46:510–512

    Google Scholar 

  26. Plum F (1970) The neurological integration of behavioural and metabolic control of breathing. In: Porter R (ed) Ciba Found Symp “Breathing, Hering Breuer centenary symposium”. Churchill, London, pp 159–170

    Google Scholar 

  27. Plum F (1982) Mechanisms of “central” hyperventilation. Ann Neurol 11:636–637

    Google Scholar 

  28. Plum F, Swanson AG (1958) Abnormalities in central regulation of respiration in acute and convalescent poliomyelitis. Arch Neurol Psychiatry 80:267–285 syndromes. In: Waksman BH (ed) Immunological mechanisms in neurology and psychiatric disease. Res Publ Assoc Res New Ment Dis 68: 187–219

    Google Scholar 

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Ball, J.A., Warner, T., Reid, P. et al. Central alveolar hypoventilation associated with paraneoplastic brain-stem encephalitis and anti-Hu antibodies. J Neurol 241, 561–566 (1994). https://doi.org/10.1007/BF00873520

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  • DOI: https://doi.org/10.1007/BF00873520

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