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Usefulness of movement time in the assessment of Parkinson's disease

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Abstract

Reaction time (RT) and movement time (MT) are reported to be delayed in Parkinson's disease (PD), but their clinical utility and relationship with clinical findings is still uncertain. We investigated RT and MT in 22 PD patients at baseline conditions and following acute oral trials of levodopa and biperiden, an anticholinergic drug. At baseline conditions, RT and MT of PD patients were abnormally delayed compared with those of 16 normal control subjects. Both RT and MT were longer in more severely affected patients compared with the mild PD patients; in the mild PD patients with asymmetrical signs both responses were longer on the more affected side. Bradykinesia was the clinical symptom that best correlated with the objective measurements, with a stronger correlation for MT than for RT. The oral administration of levodopa significantly improved both the responses, whereas biperiden was ineffective. The magnitude of RT and MT improvement after levodopa differed; MT improvement was related to PD severity, whereas RT improvement was not. These results suggest that MT, rather than RT, is an objective, simple, and reliable tool to evaluate bradykinesia and its levodopa-induced modifications in PD.

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References

  1. Angel RW, Alston W, Garland H (1971)l-Dopa and error correction time in Parkinson's disease. Neurology 21:1255–1260

    Google Scholar 

  2. Baropi A, Benvenuti F, Fantini L, Pantaleo T, Urbani F (1984) Human ballistic arm abduction movements: effect ofl-Dopa treatment in Parkinson's disease. Neurology 34:868–876

    Google Scholar 

  3. Bazalgette D, Zattara M, Bathien N, Bouisset S, Rondot P (1986) Postural adjustments associated with rapid voluntary arm movements in patients with Parkinson's disease. Adv Neurol 45:371–374

    Google Scholar 

  4. Berardelli A, Dick JPR, Rothwell JC, Day BL, Mardsen CD (1986) Scaling of the size of the first agonist EMG burst during rapid wrist movements in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 49:1273–1279

    Google Scholar 

  5. Bloxham CA, Mindel TA, Frith CD (1984) Initiation and execution of predictable and unpredictable movements in Parkinson's disease. Brain 107:371–384

    Google Scholar 

  6. Brooks DJ, Ibanez V, Scwle GV, Playford ED, Quinn N, Mathias CJ, Lees AJ, Marsden CD, Bannister R, Frackowiak RSJ (1992) Striatal D2 receptor status in patients with Parkinson's disease, striatonigral degeneration, and progressive sopranuclear palsy, measured with1 1C-raclopride and positron emission tomography. Ann Neurol 31:184–192

    Google Scholar 

  7. Calne DB, Zigmond MJ (1991) Compensatory mechanism in degenerative neurologic diseases. Insights from parkinsonism. Arch Neurol 48:361–363

    Google Scholar 

  8. Contin M, Riva R, Martinelli P, Procaccianti G, Cortelli P, Avoni P, Baruzzi A (1990) Response to a standard oral levodopa test in parkinsonian patients with and without motor fluctuations. Clin Neuropharmacol 13:19–28

    Google Scholar 

  9. Day BL, Dick JPR, Marsden CD (1984) Patients with Parkinson's disease can employ a predictive motor strategy. J Neurol Neurosurg Psychiatry 47:1299–1306

    Google Scholar 

  10. Draper IT, Johns RJ (1964) The disordered movement in Parkinsonism and the effect of drug treatment. Bull Johns Hopkins Hosp 115:465–480

    Google Scholar 

  11. Dubois B, Pillon B, Legault F, Agid Y, Lhermitte F (1988) Slowing of cognitive processing in progressive supranuclear palsy. A comparison with Parkinson's disease. Arch Neurol 45:1194–1199

    Google Scholar 

  12. Evarts EV, Teravainen H, Calne DB (1981) Reaction time in Parkinson's disease. Brain 104:167–186

    Google Scholar 

  13. Fabbrini G, Mouradian MM, Juncos JL, Schlegel J, Mohr E, Chase TN (1988) Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, part 1. Ann Neurol 24:366–371

    Google Scholar 

  14. Fabn S, Elton RL, and the Members of the UPDRS Development Committee (1987) Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Calne DB (eds) Recent developments in Parkinson's disease. MacMillan, London, pp 153–163

    Google Scholar 

  15. Flowers KA (1976) Visual “closedloop” and “open-loop” characteristics of voluntary movement in patients with parkinsonism and intention tremor. Brain 99:269–310

    Google Scholar 

  16. Flowers KA (1978) Lack of prediction in the motor behaviour of parkinsonism. Brain 101:35–52

    Google Scholar 

  17. Folstein MF, Folstein SE, Mc Hugh PR (1975) “Mini mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Google Scholar 

  18. Gancher ST, Nutt JG, Woodward WR (1987) Peripheral pharmacokinetics of levodopa in untreated, stable, and fluctuating parkinsonian patients. Neurology 37:940–944

    Google Scholar 

  19. Girotti F, Grassi MP, Carella F, Soliveri P, Musicco M, Lamperti E, Caraceni T (1986) Possible involvement of attention processes in Parkinson's disease. Adv Neurol 45:425–429

    Google Scholar 

  20. Hallett M, Khoshbin S (1980) A physiological mechanism of bradykinesia. Brain 103:301–314

    Google Scholar 

  21. Heilman KM, Bowers D, Watson RT, Greer M (1976) Reaction time in Parkinson's disease. Arch Neurol 33:139–140

    Google Scholar 

  22. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442

    Google Scholar 

  23. Horvath TB, Meares RA (1974)l-Dopa and arousal. J Neurol Neurosurg Psychiatry 37:416–421

    Google Scholar 

  24. Jankovich J (1987) Pathophysiology and clinical assessment of motor symptoms in Parkinson's disease. In: Koller WC (ed) Handbook of Parkinson's disease. Dekker, New York, pp 99–126

    Google Scholar 

  25. Kaneoke Y, Koike Y, Sakurai N, Takahashi A, Watanabe S (1989) Reaction time of movement preparation in patient's with Parkinson's disease. Neurology 39:1615–1618

    Google Scholar 

  26. Kempster PA, Frankel JP, Stern GM, Lees AJ (1990) Comparison of motor response to apomorphine and levodopa in Parkinson's disease. J Neurol Neurosurg Psychiatry 53:1004–1007

    Google Scholar 

  27. Kim M, Gash DM, Kurlan R (1990) Levodopa dose-response study in MPTP-induced hemiparkinsonian monkeys. Neurology 40 [Suppl 1]:262

    Google Scholar 

  28. Lee T, Seeman P, Rayput A, Farley IJ, Hornykiewicz O (1978) Receptor basis for dopaminergic supersensitivity in Parkinson's disease. Nature 273:59–61

    Google Scholar 

  29. Leenders KL, Aquilonius SM, Bergstrom K (1988) Unilateral MPTP lesion in a rhesus monkey: effect on the striatal dopaminergic system measured in vivo with PET using various novel tracers. Brain Res 445:61–67

    Google Scholar 

  30. Lichter DG, Corbett AJ, Fitzgibbon GM, Davidson OR, Hope JKA, Goddard GV, Sharples KJ, Pollock M (1988) Cognitive and motor dysfunction in Parkinson's disease. Clinical, performance, and computed tomographic correlations. Arch Neurol 45:854–860

    Google Scholar 

  31. Mandir AS, Watts RL, Bucholz SR, Montgomery EB (1990) Changes in primary motor cortex neuronal activity associated with increased reaction time and movement time in MPTP parkinsonism. Mov Disord 5 [Suppl 1]:77

    Google Scholar 

  32. Mishra RK, Wong YW, Varmuze SL, Tuff L (1978) Chemical lesion and drug-induced supersensitivity and subsensitivity of caudate dopamine receptors. Life Sci 23:443–446

    Google Scholar 

  33. Montgomery EB, Nuessen J (1990) The movement speed/accuracy operator in Parkinson's disease. Neurology 40:269–272

    Google Scholar 

  34. Mouradian MM, Junkos JL, Fabbrini G, Schlegel J, Bartko JJ, Chase TN (1988) Motor fluctuations in Parkinson's disease: central pathophysiological mechanisms, part II. Ann Neurol 24:372–378

    Google Scholar 

  35. Muenter MD, Tyce GM (1971)l-Dopa therapy of Parkinson's disease: plasmal-dopa concentration, therapeutic response, and side effects. Mayo Clin Proc 46:231–239

    Google Scholar 

  36. Nissinen E, Taskinen J (1982) Simultaneous determination of carbidopa, levodopa and 3,4-dihydroxyphenilacetic acid using high-performance liquid chromatography with electrochemical detection. J Chromatogr 231:459–462

    Google Scholar 

  37. Nutt JG, Carter JH, Woodward WR, Gancher ST (1990) Pharmacodynamics of chronic L-dopa administration. Neurology 40 [Suppl 1]:292

    Google Scholar 

  38. Obeso JA, Martinez-Lage JM (1987) Anticholinergic and amantadine. In: Koller WC (ed) Handbook of Parkinson's disease. Dekker, New York, pp 309–316

    Google Scholar 

  39. Ogasahara S, Nishikawa Y, Takahashi M, Wada K, Nakamura Y, Yorifuji S, Tarui S (1984) Dopamine metabolism in the central nervous system after discontinuation ofl-dopa therapy in patients with Parkinson's disease. J Neurol Sci 66:151–163

    Google Scholar 

  40. Pearce RKB, Seeman P, Jellinger K, Tourtellotte WW (1990) Dopamine uptake sites and dopamine receptors in Parkinson's disease and schizophrenia. Eur Neurol 30 [Suppl 1]:9–14

    Google Scholar 

  41. Perlmutter JS, Kilbourn MR, Raichle ME, Welch MJ (1987) MPTP-induced up-regulation of in vivo dopaminergic radioligand-receptor binding in humans. Neurology 37:1575–1579

    Google Scholar 

  42. Pullman SL, Watts RL, Juncos JL, Chase TN, Sanes JN (1988) Dopaminergic effects on simple and choice reaction time performance in Parkinson's disease. Neurology 38:249–254

    Google Scholar 

  43. Rafal RD, Posner MI, Walker JA, Friedrich FJ (1984) Cognition and basal ganglia. Separating mental and motor components of performance in Parkinson's disease. Brain 107:1083–1094

    Google Scholar 

  44. Rafal RD, Friedman JH, Lannon MC (1989) Preparation of manual movement in hemiparkinsonism. J Neurol Neurosurg Psychiatry 52:399–402

    Google Scholar 

  45. Reches A, Wagner HR, Jackson-Lewis V, Jablonskaya-Alter E, Fahn S (1984) Chronic levodopa or pergolide administration induces down-regulation of dopamine receptors in denervated striatum. Neurology 34:1208–1212

    Google Scholar 

  46. Rinne UK, Laihinen A, Rinne JO, Nagren K, Bergman J, Ruotsalainen U (1990) Positron emission tomography demonstrates dopamine D2 receptor supersensitivity in the striatum of patients with early Parkinson's disease. Mov Disord 5:55–59

    Google Scholar 

  47. Rogers D, Lees AJ, Trimble M, Stern GM (1986) Concept of bradyphrenia: a neuropsychiatric approach. Adv Neur 45:447–450

    Google Scholar 

  48. Sagar HJ, Jordan N, Cooper J, Sullivan EB (1990) The dissociation between cognition and motor control in Parkinson's disease. Neurology 40 [Suppl 1]:168

    Google Scholar 

  49. Seeman P (1980) Brain dopamine receptors. Pharmacol Rev 32:229–313

    Google Scholar 

  50. Sheridan MR, Flowers KA, Hurrel J (1987) Programming and execution of movement in Parkinson's disease. Brain 110:1247–1271

    Google Scholar 

  51. Starkstein SE, Esteguy M, Berthier ML, Garcia H, Leiguarda R (1989) Evoked potential, reaction time and cognitive performance in on and off phases of Parkinson's disease. J Neurol Neurosurg Psychiatry 52:338–340

    Google Scholar 

  52. Steg G, Ingvarsson PE, Johnels B, Valls M, Thorselius M (1989) Objective measurement of motor disability i Parkinson's disease. Acta Neurol Scand 126:67–75

    Google Scholar 

  53. Stelmach GE, Worringham CJ, Strand EA (1986) Movement preparation in Parkinson's disease. The use of advance information. Brain 109:1179–1194

    Google Scholar 

  54. Stern Y, Mayeux R, Cotè L (1984) Reaction time and vigilance in Parkinson's disease. Arch Neurol 41:1086–1089

    Google Scholar 

  55. Teasdale N, Phillips J, Stelmach GE (1990) Temporal movement control in patients with Parkinson's disease. J Neurol Neurosurg Psychiatry 53:862–868

    Google Scholar 

  56. Teravainen H, Calne D (1980) Quantitative assessment of Parkinsonian deficits. In: Rinne UK, Klinger M, Stamm G (eds) Parkinson's disease. Current progress, problems and management. Elsevier, Amsterdam, pp 145–164

    Google Scholar 

  57. Trouche E, Beaubaton D, Amato G, Viallet F, Legallet E (1984) Changes in reaction time after pallidal or nigral lesion in the monkey. Adv Neurol 40:29–38

    Google Scholar 

  58. Velasco F, Velasco M (1973) A quantitative evaluation of the effects of LDopa on Parkinson's disease. Neuropharmacology 12:89–99

    Google Scholar 

  59. Viallet F, Massion J, Massarino R, Khalil R (1987) Performance of a bimanual load-lifting task by parkinsonian patients. J Neurol Neurosurg Psychiatry 50:1274–1283

    Google Scholar 

  60. Warabi T, Yanagisawa N, Shindo R (1988) Changes in strategy of aiming task in Parkinson's disease. Brain 111:497–505

    Google Scholar 

  61. Ward CD, Sanes JN, Dambrosia JM, Calne DB (1983) Methods for evaluating treatment in Parkinson's disease. Adv Neurol 37:1–7

    Google Scholar 

  62. Webster DD (1968) Clinical analysis of the disability in Parkinson's disease. Modern Treat 5:257–282

    Google Scholar 

  63. Wilson SAK (1925) Disorders of motility and of muscle tone, with special reference to the corpus striatum. Lancet II:1–10

    Google Scholar 

  64. Worringham CJ, Stelmach GE (1990) Practice effect of the preprogramming of discrete movements in Parkinson's disease. J Neurol Neurosurg Psychiatry 53:702–704

    Google Scholar 

  65. Yahr MD (1981) Pharmacological treatment of Parkinson's disease in early and late phases. In: Rose FC, Capildeo R (eds) Research progress in Parkinson's disease. Pitman, London, pp 233–240

    Google Scholar 

  66. Yanagisawa N, Fujimoto S, Tamaru F (1989) Bradykinesia in Parkinson's disease: disorders of onset and execution of fast movement. Eur Neurol 29 [Suppl 1]:19–28

    Google Scholar 

  67. Yokochi F, Nakamura R, Narabayashi (1985) Reaction time of patients with Parkinson's disease, with reference to asymmetry of neurological signs. J Neurol Neurosurg Psychiatry 48:702–705

    Google Scholar 

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  1. Istituto di Scienze Neurologiche, Policlinico “Mater Domini”, Via T. Campanella, 1-88100, Catanzaro, Italy

    Mario Zappia, Rita Montesanti, Rosanna Colao & Aldo Quattrone

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  1. Mario Zappia
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Zappia, M., Montesanti, R., Colao, R. et al. Usefulness of movement time in the assessment of Parkinson's disease. J Neurol 241, 543–550 (1994). https://doi.org/10.1007/BF00873517

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