2-mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria
- 36 Downloads
A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50–300 µmol/24 h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the metabolite could be a potential hazard in oxidation of fatty acids.
Key words2-mercaptopropionyl-glycine cystinuria 2-mercaptopropionate metabolism
Unable to display preview. Download preview PDF.
- 1.Hautman RE (1981) Cystine stone — therapy with alpha-mercaptopropionyl-glycine — ten years of experience with forty-two patients. In: Smith LH, Robertson W, Finlayson B (eds) Urolithiasis, clinical and basic research. Plenum Press, New York, pp 139–143Google Scholar
- 2.Denneberg T, Jeppson JO, Stenberg P (1983) Alternative treatment of cystinuria withα-mercaptopropionyl-glycine, Thiola Proc EDTA 20: 427–432Google Scholar
- 3.Hannestad U, Sörbo B (1979) Determination of 3-mercaptolactate, mercaptoacetate andN-acetylcystine in urine by gas chromatography. Clin Chem Acta 95: 189–200Google Scholar
- 4.Kågedal B, Källberg M, Mårtensson J (1984) Determination of non-protein-boundN-acetylcysteine in plasma by high-performance liquid chromatography. J Chromatogr 311: 170–175Google Scholar
- 5.Kågedal B, Carlsson M, Denneberg T (1986) Determination ofα-mercaptopropionyl-glycine in plasma and urine by high-performance liquid chromatography. J Chromatogr (in press)Google Scholar
- 6.Sörbo B, Hannestad U, Lunquist P, Mårtensson J, Öhman S (1980) Clinical chemistry of mercaptopyrovate and its metabolites. In: Cavallini D, Gaull GE, Zappia W (eds) Natural sulfur compounds. Plenum, New York, pp 463–468Google Scholar
- 7.Bauche F, Saboralt D, Guidicelli Y, Nordmann J, Nordmann R (1983) Inhibition in vitro of acyl-CoA-dehydrogenases by 2-mercaptoacetate in rat liver mitochondria. Biochem J 215: 457–464Google Scholar
- 8.Sabbagh E, Cuebas D, Schultz H (1985) 3-Mercaptopropionic acid, a potent inhibitor of fatty acid oxidation in rat heart mitochondria. J Biol Chem 260: 7337–7342Google Scholar