European Journal of Clinical Pharmacology

, Volume 31, Issue 1, pp 119–121 | Cite as

2-mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria

  • J. Mårtensson
  • T. Denneberg
  • B. Kågedal
Short Communications

Summary

A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50–300 µmol/24 h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the metabolite could be a potential hazard in oxidation of fatty acids.

Key words

2-mercaptopropionyl-glycine cystinuria 2-mercaptopropionate metabolism 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Mårtensson
    • 1
  • T. Denneberg
    • 2
  • B. Kågedal
    • 1
  1. 1.Department of Clinical ChemistryUniversity HospitalLinköpingSweden
  2. 2.Department of NephrologyUniversity HospitalLinköpingSweden

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