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Acute changes in renal function induced by bisoprolol, a new cardioselective beta-blocking agent

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The acute effects of bisoprolol 10 mg i.v., a new beta1-selective adrenoceptor antagonist, on heart rate, mean blood pressure (mBP), glomerular filtration rate (GFR), para-aminohippuric acid clearance (CPAH), sodium clearance, urine volume and plasma renin activity (PRA), were studied in 6 patients with essential hypertension. Heart rate decreased by 23%, mBP remained unchanged, and GFR decreased by 14% and CPAH by 23%. PRA was depressed on average by 25%. Urine volume and sodium clearance also declined by 9 and 13%, respectively, but the changes were not statistically significant. The fall in heart rate was significantly correlated with that in GFR and CPAH. Changes in GFR were correlated significantly with those in CPAH. The acute changes in renal function induced by bisoprolol are considered to be due to a reduction in cardiac output and increased systemic vascular resistance.

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  1. 1.

    Carriere S (1969) Effect of norepinephrine, isoproteronol and adrenergic blockers upon the intrarenal distribution of blood flow. Can J Physiol Pharmacol 47: 199–208

  2. 2.

    Nies AS, McNeil JS, Schrier RW (1971) Mechanism of increased sodium reabsorption during Propranolol administration. Circulation 44: 596–604

  3. 3.

    Wilkinson R (1982) Beta-blockers and renal function. Drugs 23: 195–206

  4. 4.

    Cohn JN (1983) Haemodynamic effects of beta-blockers. Drugs 25 [Suppl 2]: 100–102

  5. 5.

    Schirmeister J, Decot M, Hallauer W, Willmann H (1966) Beta-Receptoren und renale Haemodynamik des Menschen. Arzneimittelforsch 16: 847–850

  6. 6.

    Bufano G, Pacentini L (1969) Studio comparativo dell'influenza esercitata da agonisti e antagonisti beta-adrenergici sulla funzione renale dell'uomo normale. Minerva Med 60: 1229–1232

  7. 7.

    Sullivan JM, Adams DF, Hollenberg NK (1976) Beta-adrenergic blockade in essential hypertension: Reduced renin release despite renal vasoconstriction. Circ Res 39: 532–536

  8. 8.

    Heierli C, Thoelen H, Radielovic P (1977) Renal function following a single dose of pindolol in hypertensive patients with varying degrees of impairment of renal function. Int J Clin Pharmacol 15: 65–71

  9. 9.

    Zech P, Pozet N, Labeeuw M, Sassard J, Bernheim J, Pellet M, Traeger J (1976) Acute renal effects of new beta-adrenergic receptor site blocking agents on renal function. Proc Eur Dial Transplant Assoc 12: 203–209

  10. 10.

    Swainson CP, Robson JS, Goodfellow RM (1980) Effect of beta-adrenergic blockade on renal function during exercise. Seventh Scientific Meeting of ISH, New Orleans

  11. 11.

    Duchin K, Antonaccio M, Steinbacher T (1978) Novel effects of nadolol, a new beta-adrenoceptor antagonist on renal function: Comparison with Propranolol. Circulation 58: II-183

  12. 12.

    Hollenberg NK, Adams DF, McKinstry DN, Williams GH, Borucki LJ, Sullivan JM (1979) Beta-adrenoceptor-blocking agents and the kidney: Effect of nadolol and propranolol on renal circulation. Br J Clin Pharmacol 1 [Suppl 2]: 219s–225s

  13. 13.

    Bianchi C, Bonadio M, Donadio C, Tramonti G, Figus S, Papalexiou P (1976) Acute effects of tolamolol on renal function in hypertensive patients. Experientia 32: 1565–1566

  14. 14.

    Tattersfield AE, Cragg DJ, Bacon RJ (1984) Assessment of beta-adrenoceptor selectivity of a new beta-adrenoceptor antagonist, bisoprolol, in man. Br J Clin Pharmacol 18: 343–347

  15. 15.

    Goldring W, Chasis H (1944) Hypertension and hypertensive disease. New York, The Commonwealth Fund

  16. 16.

    Reubi FC (1963) Clearance tests in clinical medicine. CC Thomas, Springfield, Ill

  17. 17.

    Vorburger C, Riedwyl H, Reubi FC (1969) Vergleichende Studien zwischen den renalen Clearances von51CR-EDTA, Inulin und Natriumthiosulfat beim Menschen. Klin Wochenschr 47: 415–420

  18. 18.

    Sealey JE, Gerten-Banes J, Laragh JH (1972) The renin system. Variations in man measured by radioimmuno-assay or bioassay. Kidney Int 1: 240–253

  19. 19.

    Ulrich M, Frohlich ED, Dustan HP, Page IH (1968) Immediate hemodynamic effects of beta-adrenergic blockade with propranolol in normotensive and hypertensive man. Circulation 37: 411–416

  20. 20.

    Reubi FC (1978) Role of physical factors in the acute changes in renal function elicited by antihypertensive drugs. Eur J Clin Pharmacol 13: 185–193

  21. 21.

    Bühler FR, Marbet G, Patel U, Burkart F (1975) Renin-suppressive potency of various beta-adrenergic blocking agents at supine rest and during upright exercise. Clin Sci Mol Med 48: 61s–64s

  22. 22.

    Bauer JH, Brooks CS, Burch RN (1982) Renal Function and hemodynamic studies in low and normal renin essential hypertension. Arch Int Med 142: 1317–1323

  23. 23.

    Reubi FC, Vorburger C, Bütikofer E (1970) A comparison of the short-term and long-term hemodynamic effects of antihypertensive drug therapy. In: Conolly ME (ed) Catapres in hypertension. Butterworth, London, p 113–125

  24. 24.

    Reubi FC (1977) Le retentissement rénal des traitements antihypertenseurs. J Urol Néphrol 83: 296–302

  25. 25.

    Ibsen H, Sederberg-Olsen P (1973) Changes in glomerular filtration rate during long-term treatment with propranolol in patients with arterial hypertension. Clin Sci 44: 129–134

  26. 26.

    Waal-Manning HJ (1979) Atenolol and three non-selective beta-blockers in hypertension. Clin Pharmacol Ther 25: 8–18

  27. 27.

    Bauer JH (1983) Effects of propranolol therapy on renal function and body fluid composition. Arch Intern Med 143: 927–931

  28. 28.

    Wilkinson R, Stevens IM, Pickering M, Robson V, Hawkins T, Keer DNS, Harry JD (1980) A study of the effects of atenolol and propranolol on renal function in patients with essential hypertension. Br J Clin Pharmacol 10: 51–59

  29. 29.

    Waal-Manning HJ, Bolli P (1980) Atenolol v. placebo in mild hypertension: Renal, metabolic and stress antipressor effects. Br J Clin Pharmacol 9: 553–560

  30. 30.

    Rasmussen S, Rasmussen K (1979) Influence of metoprolol alone and in combination with a thiazide diuretic on blood pressure, plasma volume, extracellular volume and glomerular filtration rate in essential hypertension. Europ J Clin Pharmacol 15: 305–310

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Glück, Z., Reubi, F.C. Acute changes in renal function induced by bisoprolol, a new cardioselective beta-blocking agent. Eur J Clin Pharmacol 31, 107–111 (1986).

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Key words

  • bisoprolol
  • heart rate
  • blood pressure
  • renal clearance
  • PAH clearance
  • glomerular filtration rate
  • plasma renin activity