Summary
The effect on bronchial smooth muscle of slow release theophylline plus placebo and theophylline plus slow release nifedipine administered for a prolonged period to 12 asthmatic and hypertensive patients has been studied. Both combinations led to a significant improvement in respiratory function parameters when compared to baseline values. No additional improvement in pulmonary function was found on long term treatment with theophylline plus nifedipine. A reduction in the number of asthmatic attacks, in the use of inhaled beta2-agonists and better control of arterial blood pressure resulted from use of theophylline plus nifedipine. That drug combination is safe and valuable in patients with chronic bronchial obstruction and cardiovascular disease.
References
Spedini C, Lombardi C (1986) Calcium antagonists in COPD. Chest 89: 315–316
Lombardi C, Spedini C, Govoni S (1985) Effect of calcium entry blockade on ethanol-induced changes in bronchomotor tone. Eur J Clin Pharmacol 28: 221–222
Williams DO, Barnes PJ, Vickers HP, Rudolf M (1981) Effect of nifedipine on bronchomotor tone and histamine reactivity in asthma. Br Med J 283: 348
Sturani C, Bassein L, Schiavina M, Gunella G (1983) Oral nifedipine in chronic cor pulmonale secondary to severe chronic obstructive pulmonary disease. Short and long-term hemodynamic effects. Chest 84: 135
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Spedini, C., Lombardi, C. Long-term treatment with oral nifedipine plus theophylline in the management of chronic bronchial asthma. Eur J Clin Pharmacol 31, 105–106 (1986). https://doi.org/10.1007/BF00870996
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00870996