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A new paracetamol/paracetamol-methionine ester combination effects on postoperative course

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Summary

The SUR 2647 combination is a sachet formulation containing free paracetamol and its N-acetyl-methionate ester (SUR 2647). In a randomized, singel-blind, within-patient study the effect of the SUR 2647 combination on the postoperative course was investigated in 30 out-patients after bilateral oral surgery. On one occasion they received sachets of SUR 2647 combination 2 b.i.d. (equivalent to 2 g paracetamol ×2) on the day of operation, and one sachet b.i.d. (equivalent to 1 g paracetamol ×2) on the following two days. On the other occasion they received placebo caplets. The observed mean reduction in swelling on the third (16%) and seventh (34%) postoperative days after receiving active drug was not significantly different as compared to placebo, nor was there a significant difference between the two treatments with respect to oral temperature, mouth-opening capability or postoperative bleeding. Pain after the SUR 2647 combination regime was significantly lower (P<0.01) than placebo until the second postoperative evening. Complaints were registered in both treatment groups, although reports of mild to moderate drowsiness were more common after the SUR 2647 combination.

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Authors and Affiliations

  1. Institute of Pharmacology and Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway

    L. A. Skoglund

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  1. L. A. Skoglund
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Skoglund, L.A. A new paracetamol/paracetamol-methionine ester combination effects on postoperative course. Eur J Clin Pharmacol 31, 45–48 (1986). https://doi.org/10.1007/BF00870984

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  • DOI: https://doi.org/10.1007/BF00870984

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