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European Journal of Clinical Pharmacology

, Volume 31, Issue 1, pp 23–26 | Cite as

5-Aminosalicylic acid in patients with an ileo-rectal anastomosis

A comparison of the fate of sulfasalazine and Pentasa
  • S. Bondesen
  • U. Tage-Jensen
  • O. Jacobsen
  • S. H. Hansen
  • S. N. Rasmussen
  • E. F. Hvidberg
Originals

Summary

The pharmacokinetics of 5-aminosalicylic acid (5-ASA) from sulphasalazine (SASP) and the slow-release 5-ASA preparation Pentasa was investigated in a cross-over study in 9 otherwise healthy patients with an ileo-rectal anastomosis. The 24-hour recoveries of the drugs were 90.5% and 84.7%, respectively. The median release of 5-ASA from SASP was 50% and from Pentasa 75%. Equal amounts of 5-ASA (18.0% vs 17.9%) were found in the faeces, and a significantly larger amount (4.4% vs 28.9%) of the metaboliteN-acetyl-5-aminosalicylic acid (ac-5-ASA) was found in faeces following Pentasa. A larger amount of 5-ASA was absorbed and subsequently excreted in the urine, mainly as the metabolite (2.5% vs 20.5%) from Pentasa. This confirms previous results in ileostomized patients treated with Pentasa. The present findings also demonstrate that bacterial azo-reduction of SASP in patients with ileorectal anastomosis may be an adequate way to deliver 5-ASA in this type of patient. Both treatments may be used in these patients during a flare up of ulcerative colitis, but randomized studies are needed.

Key words

sulphasalazine Pentasa slow release preparation 5-aminosalicylic acid ileo-rectal anastomosis ulcerative colitis pharmacokinetics 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • S. Bondesen
    • 1
  • U. Tage-Jensen
    • 2
  • O. Jacobsen
    • 3
  • S. H. Hansen
    • 4
  • S. N. Rasmussen
    • 2
  • E. F. Hvidberg
    • 5
  1. 1.Department of MedicineCommunity HospitalElsinoreDenmark
  2. 2.Department of Medical Gastroenterology FGlostrup HospitalCopenhagenDenmark
  3. 3.Department of Medicine P, Division of Gastroenterology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
  4. 4.Department of Organic ChemistryRoyal Danish School of PharmacyCopenhagenDenmark
  5. 5.Department of Clinical Pharmacology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark

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